Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack.
Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack.
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DOI：
10.1111/j.1742-4658.2012.08653.x
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Harroch S
中科院分区：
文献类型：
--
作者：
Mohebiany AN;Nikolaienko RM;Bouyain S;Harroch S
可逆的蛋白质磷酸化在细胞间通讯中起着关键作用。与蛋白酪氨酸激酶一起，蛋白酪氨酸磷酸酶（PTP）通过控制不同效应物的磷酸化水平参与关键细胞过程的调节。在PTP中，受体样蛋白酪氨酸磷酸酶（RPTP）参与重要的发育过程，特别是神经系统的形成。直到最近，很少有配体已被确定为RPTPs，使其难以掌握这些受体对细胞过程的影响，以及通过其功能介导的机制。然而，现在已经确定了几个潜在的RPTP配体，为我们提供了无与伦比的洞察RPTP功能。在这篇综述中，我们将集中在这些RPTP及其相关配体之间的细胞外相互作用的性质和生物学后果。
Reversible protein phosphorylation plays a pivotal role in intercellular communication. Together with protein tyrosine kinases, protein tyrosine phosphatases (PTPs) are involved in the regulation of key cellular processes by controlling the phosphorylation levels of diverse effectors. Among PTPs, receptor-like protein tyrosine phosphatases (RPTPs) are involved in important developmental processes, particularly in the formation of the nervous system. Until recently, few ligands had been identified for RPTPs, making it difficult to grasp the effects these receptors have on cellular processes as well as the mechanisms through which their functions are mediated. However, several potential RPTP ligands have now been identified to provide us with unparalleled insights into RPTP function. In this review, we will focus on the nature and biological outcomes of these extracellular interactions between RPTPs and their associated ligands.
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