MicroRNAs as a therapeutic target for cardiovascular diseases.
MicroRNAs as a therapeutic target for cardiovascular diseases.
复制标题
DOI：
10.1111/j.1582-4934.2009.00744.x
复制
发表时间：
2009-04
影响因子：
5.3
通讯作者：
Tyagi SC
中科院分区：
文献类型：
--
作者：
Mishra PK;Tyagi N;Kumar M;Tyagi SC
微小RNA（microRNAs，miRNAs）是一类微小的内源性保守非编码RNA，通过促进mRNA的降解或通过翻译抑制下调蛋白质的产生来负调控基因的表达。它们维持细胞蛋白质的最佳剂量，因此在生物功能的调节中发挥关键作用。最近发现的心脏中的miRNAs及其在病理条件下的差异表达提供了未被发现的心血管疾病的调控机制一瞥。近50种miRNAs在小鼠心脏中过表达。一些miRNA在心血管疾病中的作用已被充分证明，例如在心律失常中的miRNA-1，在心脏纤维化中的miRNA-29，在血管生成中的miRNA-126和在心脏肥大中的miRNA-133。心力衰竭期间Dicer（所有miRNAs成熟所需的酶）的异常表达表明其直接参与心脏疾病的调节。MiRNA和Dicer以时空方式在心脏和血管组织中提供了一个特定的精确基因调控网络层，表明它们作为治疗的强大干预工具的意义。在干细胞中操纵miRNA以实现其靶向分化和优化miRNA向所需细胞的递送模式的组合策略将决定miRNA治疗疾病的未来潜力。本文综述了心血管疾病microRNomics的最新研究进展，以及miRNAs作为潜在治疗靶点的未来--可能面临的挑战和应对措施。
MicroRNAs (miRNAs) are tiny, endogenous, conserved, non-coding RNAs that negatively modulate gene expression by either promoting the degradation of mRNA or down-regulating the protein production by translational repression. They maintain optimal dose of cellular proteins and thus play a crucial role in the regulation of biological functions. Recent discovery of miRNAs in the heart and their differential expressions in pathological conditions provide glimpses of undiscovered regulatory mechanisms underlying cardiovascular diseases. Nearly 50 miRNAs are overexpressed in mouse heart. The implication of several miRNAs in cardiovascular diseases has been well documented such as miRNA-1 in arrhythmia, miRNA-29 in cardiac fibrosis, miRNA-126 in angiogenesis and miRNA-133 in cardiac hypertrophy. Aberrant expression of Dicer (an enzyme required for maturation of all miRNAs) during heart failure indicates its direct involvement in the regulation of cardiac diseases. MiRNAs and Dicer provide a particular layer of network of precise gene regulation in heart and vascular tissues in a spatiotemporal manner suggesting their implications as a powerful intervention tool for therapy. The combined strategy of manipulating miRNAs in stem cells for their target directed differentiation and optimizing the mode of delivery of miRNAs to the desired cells would determine the future potential of miRNAs to treat a disease. This review embodies the recent progress made in microRNomics of cardiovascular diseases and the future of miRNAs as a potential therapeutic target - the putative challenges and the approaches to deal with it.
登录
查看更多内容
影响因子：
5.3
作者：
Davis, Tigwa H.;Cuellar, Trinna L.;Ullian, Erik M.
通讯作者：
Ullian, Erik M.
影响因子：
64.5
作者：
Foerstemann, Klaus;Horwich, Michael D.;Zamore, Phillip D.
通讯作者：
Zamore, Phillip D.
影响因子：
7.3
作者：
Fish JE;Srivastava D
通讯作者：
Srivastava D
影响因子：
48
作者：
Ebert, Margaret S.;Neilson, Joel R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.
DOI：
10.1073/pnas.0710228105
发表时间：
2008-02-12
影响因子：
11.1
作者：
Chen, Jian-Fu;Murchison, Elizabeth P.;Wang, Da-Zhi
通讯作者：
Wang, Da-Zhi