Relationship between electrode position and temporal modulation sensitivity in cochlear implant users: Are close electrodes always better?
Relationship between electrode position and temporal modulation sensitivity in cochlear implant users: Are close electrodes always better?
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DOI：
10.1016/j.heliyon.2022.e12467
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发表时间：
2023-02
期刊：
影响因子：
4
通讯作者：
Holden, Timothy A.
中科院分区：
文献类型：
--
作者：
Zhou, Ning;Shi, Xuyang;Dixit, Omkar;Firszt, Jill B.;Holden, Timothy A.
关键词：
时间调制灵敏度已被广泛研究人工耳蜗（CI）用户，由于其强大的相关性，语音识别结果。先前的研究报道，时间调制检测阈值（MDT）在整个tonotopic轴上变化，并将这种变化归因于斑片状神经存活。然而，在动物模型中确定的神经健康的相关性取决于人体中的电极位置。尽管如此，MDT和电极位置之间的关系尚未探讨。我们测试了13只耳朵的距离对调制灵敏度的影响，特别是针对电极靠近蜗轴是否普遍有益的问题。这项研究的参与者是舌后语言的使用者和皮质核CI的使用者。从使用计算机断层扫描（CT）成像获得的扫描测量每个电极与耳蜗内侧壁（MW）和蜗轴中轴（MMA）的距离。距离测量与在所选电极上测量的空间调谐曲线的斜率相关，以调查电极位置是否至少部分地占神经兴奋的宽度。根据以前的研究结果，电极位置解释了24%的空间调谐曲线斜率的方差。还测量了MDT的所有功能电极。5只耳朵的MDT和至少一个距离测量值之间呈正相关; 6只耳朵呈负相关，其余两只耳朵无相关性。显示MDT-距离正相关的耳朵，因此受益于电极靠近神经元件，是那些在两个语音识别测量中表现更好的耳朵，即，语音接收阈值（SRT）和AzBio句子的识别。这些结果可能表明，能够利用电极近端放置的耳朵可能具有更好的语音识别结果。先前的人类组织学研究表明，语音识别与螺旋神经节细胞计数相关。或者，具有良好语音识别结果的耳朵可能具有良好的整体神经健康，这是闭合电极产生促进调制灵敏度的空间受限神经激励模式的先决条件。这些发现表明，减少通道相互作用的方法，例如，环抱蜗轴电极阵列或电流聚焦可能仅对CI用户的一部分有益。此外，这表明术前估计神经存活对于选择最合适的电极阵列类型（蜗轴周围与侧壁）以实现最佳植入物功能非常重要。
Temporal modulation sensitivity has been studied extensively for cochlear implant (CI) users due to its strong correlation to speech recognition outcomes. Previous studies reported that temporal modulation detection thresholds (MDTs) vary across the tonotopic axis and attributed this variation to patchy neural survival. However, correlates of neural health identified in animal models depend on electrode position in humans. Nonetheless, the relationship between MDT and electrode location has not been explored. We tested 13 ears for the effect of distance on modulation sensitivity, specifically targeting the question of whether electrodes closer to the modiolus are universally beneficial. Participants in this study were postlingually deafened and users of Cochlear Nucleus CIs. The distance of each electrode from the medial wall (MW) of the cochlea and mid-modiolar axis (MMA) was measured from scans obtained using computerized tomography (CT) imaging. The distance measures were correlated with slopes of spatial tuning curves measured on selected electrodes to investigate if electrode position accounts, at least in part, for the width of neural excitation. In accordance with previous findings, electrode position explained 24% of the variance in slopes of the spatial tuning curves. All functioning electrodes were also measured for MDTs. Five ears showed a positive correlation between MDTs and at least one distance measure across the array; 6 ears showed negative correlations and the remaining two ears showed no relationship. The ears showing positive MDT-distance correlations, thus benefiting from electrodes being close to the neural elements, were those who performed better on the two speech recognition measures, i.e., speech reception thresholds (SRTs) and recognition of the AzBio sentences. These results could suggest that ears able to take advantage of the proximal placement of electrodes are likely to have better speech recognition outcomes. Previous histological studies of humans demonstrated that speech recognition is correlated with spiral ganglion cell counts. Alternatively, ears with good speech recognition outcomes may have good overall neural health, which is a precondition for close electrodes to produce spatially confined neural excitation patterns that facilitate modulation sensitivity. These findings suggest that the methods to reduce channel interaction, e.g., perimodiolar electrode array or current focusing, may only be beneficial for a subgroup of CI users. Additionally, it suggests that estimating neural survival preoperatively is important for choosing the most appropriate electrode array type (perimodiolar vs. lateral wall) for optimal implant function.
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DOI：
10.1007/s10162-005-0007-6
发表时间：
2005-09-01
影响因子：
2.4
作者：
Galvin, JJ;Fu, QJ
通讯作者：
Fu, QJ
影响因子：
3.7
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影响因子：
2.4
作者：
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通讯作者：
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影响因子：
3.7
作者：
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影响因子：
1.4
作者：
NADOL, JB;YOUNG, YS;GLYNN, RJ
通讯作者：
GLYNN, RJ