Protective Effect of 2-Hydroxymethyl Anthraquinone from Hedyotis diffusa Willd in Lipopolysaccharide-Induced Acute Lung Injury Mediated by TLR4-NF-κB Pathway
Protective Effect of 2-Hydroxymethyl Anthraquinone from Hedyotis diffusa Willd in Lipopolysaccharide-Induced Acute Lung Injury Mediated by TLR4-NF-κB Pathway
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白花蛇舌草2-羟甲基蒽醌对TLR4-NF-κB通路介导的脂多糖诱导的急性肺损伤的保护作用
DOI：
10.1007/s10753-018-0857-9
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发表时间：
2018-08
期刊：
影响因子：
5.1
通讯作者：
Weixing Shen
中科院分区：
文献类型：
--
作者：
Jiani Tan;Liu Li;Wenjing Shi;Dongdong Sun;Changliang Xu;Yunjie Miao;Huisen Fan;Jianrong Liu;Haibo Cheng;Mianhua Wu;Weixing Shen
Chronic inflammation and oxidant/antioxidant imbalance play a prominent role in inflammatory lung diseases. 2-Hydroxymethyl anthraquinone (HMA), an anthraquinone derivative found in Hedyotis diffusa Willd, has been reported to have broad-spectrum anti-inflammatory effects; the present study was conducted to investigate the protective effect of HMA in LPS-induced acute lung injury (ALI) and to explore its potential molecular mechanisms. The results showed that HMA remarkably attenuated LPS-induced pulmonary edema, myeloperoxidase activity, and inflammatory cytokine production. Besides, HMA showed significant antioxidative activity; it raised the levels of SOD and GSH and depleted the MDA level in serum of ALI mice. In vitro, HMA suppressed the production NO, TGF-β1, TNF-α, IL-6, and IL-1β in LPS-stimulated RAW 264.7 macrophage cells. The western blot analysis showed that TLR4 expression and the activation of NF-κB were antagonized by HMA. Moreover, addition of exogenous NF-κB inhibitor BAY11-7082 weakened the inhibitory effects of HMA in inflammatory cytokines and ROS production. Taken together, these findings provide the first experimental evidence supporting that HMA has protective effects on LPS-induced inflammation, which is mediated by TLR4-NF-κB pathway.
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影响因子：
4.2
作者：
Kemegne GA;Mkounga P;Essia Ngang JJ;Sado Kamdem SL;Nkengfack AE
通讯作者：
Nkengfack AE
影响因子：
2.7
作者：
Dzoyem, Jean Paul;Donfack, Arno R. N.;Eloff, Jacobus N.
通讯作者：
Eloff, Jacobus N.
影响因子：
7.4
作者：
Circu, Magdalena L.;Aw, Tak Yee
通讯作者：
Aw, Tak Yee
影响因子：
5.4
作者：
Meng, Qiu-xia;Roubin, Rebecca H.;Hanrahan, Jane R.
通讯作者：
Hanrahan, Jane R.
影响因子：
8.8
作者：
Fan E;Dowdy DW;Colantuoni E;Mendez-Tellez PA;Sevransky JE;Shanholtz C;Himmelfarb CR;Desai SV;Ciesla N;Herridge MS;Pronovost PJ;Needham DM
通讯作者：
Needham DM