Reactive oxygen species, cellular redox systems, and apoptosis.
Reactive oxygen species, cellular redox systems, and apoptosis.
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DOI：
10.1016/j.freeradbiomed.2009.12.022
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发表时间：
2010-03-15
影响因子：
7.4
通讯作者：
Aw, Tak Yee
中科院分区：
文献类型：
--
作者：
Circu, Magdalena L.;Aw, Tak Yee
关键词：
活性氧（ROS）是正常代谢和外源性暴露的产物，取决于浓度，ROS对细胞和组织可能有益或有害。在生理低水平下，ROS在细胞内信号传导和调节中充当“氧化还原信使”，而过量的ROS诱导细胞大分子的氧化修饰，抑制蛋白质功能并促进细胞死亡。此外，各种氧化还原系统，如谷胱甘肽、硫氧还蛋白和吡啶核苷酸氧化还原对，参与细胞信号传导和细胞功能的调节，包括凋亡性细胞死亡。细胞凋亡是由细胞外和细胞内信号通过两个主要途径启动的，即死亡受体介导的途径。氧化应激诱导的细胞凋亡信号传导可导致各种病理学，其是ROS增加和/或抗氧化剂减少、细胞内氧化还原稳态破坏和脂质、蛋白质或DNA的不可逆氧化修饰的结果。在当前的综述中，我们重点介绍了细胞凋亡信号中ROS和氧化还原机制的几个关键方面，并强调了知识的差距和进一步研究的潜在途径。充分了解氧化还原控制凋亡的启动和执行，可以支持针对氧化应激相关疾病的治疗干预措施的发展。
Reactive oxygen species (ROS) are products of normal metabolism and xenobiotic exposure, and depending on concentrations, ROS can be beneficial or harmful to cells and tissues. At physiological low levels, ROS function as “redox messengers” in intracellular signaling and regulation while excess ROS induce oxidative modification of cellular macromolecules, inhibit protein function and promote cell death. Additionally, various redox systems, such as the glutathione, thioredoxin, and pyridine nucleotide redox couples, participate in cell signaling and modulation of cell function, including apoptotic cell death. Cell apoptosis is initiated by extracellular and intracellular signals via two main pathways, the death receptor- or mitochondria-mediated pathways. Various pathologies can result from oxidative stress induced apoptotic signaling that is consequent to ROS increases and/or antioxidant decreases, disruption of intracellular redox homeostasis, and irreversible oxidative modifications of lipid, protein or DNA. In the current review, we focused on several key aspects of ROS and redox mechanisms in apoptotic signaling, and highlighted the gaps in knowledge and potential avenues for further investigation. A full understanding of redox control of apoptotic initiation and execution could underpin the development of therapeutic interventions targeted at oxidative stress associated disorders.
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影响因子：
7.4
作者：
Barbouti, Alexandra;Amorgianiotis, Christos;Galaris, Dimitrios
通讯作者：
Galaris, Dimitrios
影响因子：
4.3
作者：
Bolanos, Juan P.;Delgado-Esteban, Maria;Almeida, Angeles
通讯作者：
Almeida, Angeles
影响因子：
7.4
作者：
Circu, Magdalena L.;Rodriguez, Cynthia;Aw, Tak Yee
通讯作者：
Aw, Tak Yee
影响因子：
3.5
作者：
Borutaite, V;Brown, GC
通讯作者：
Brown, GC
影响因子：
64.8
作者：
Baines, CP;Kaiser, RA;Molkentin, JD
通讯作者：
Molkentin, JD