Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight.
Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight.
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DOI：
10.1016/j.cmet.2009.11.009
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发表时间：
2010-01
期刊：
影响因子：
29
通讯作者：
Zingman LV
中科院分区：
文献类型：
--
作者：
Alekseev AE;Reyes S;Yamada S;Hodgson-Zingman DM;Sattiraju S;Zhu Z;Sierra A;Gerbin M;Coetzee WA;Goldhamer DJ;Terzic A;Zingman LV
调节肌肉能量使用的代谢过程是身体能量平衡的主要决定因素。在这里，我们发现肌层atp敏感的K+ (KATP)通道，将膜兴奋性与细胞代谢途径结合起来，在生理刺激下决定肌肉的能量消耗。在运动活动和血液底物可用性不变的情况下，KATP通道功能的破坏会引起心脏和骨骼肌性能的额外能量消耗。缺乏KATP通道的横纹肌的低效燃料代谢减少了糖原和脂肪体库，促进了瘦表型。在高脂肪饮食下，由KATP通道缺陷导致的体重减轻倾向持续存在，但肥胖限制是以身体耐力受损为代价的。因此，肌上皮KATP通道控制着肌肉的能量经济性，其以组织特异性方式的下调可以通过使肌肉在休息时增加产热而在运动时降低燃料效率来提供一种抗肥胖策略。
Metabolic processes that regulate muscle energy use are major determinants of bodily energy balance. Here we find that sarcolemmal ATP-sensitive K+ (KATP) channels, which couple membrane excitability with cellular metabolic pathways, set muscle energy expenditure under physiological stimuli. Disruption of KATP channel function provoked, in conditions of unaltered locomotor activity and blood substrate availability, an extra energy cost of cardiac and skeletal muscle performance. Inefficient fuel metabolism in KATP channel-deficient striated muscles reduced glycogen and fat body depots promoting a lean phenotype. The propensity to lesser body weight imposed by KATP channel deficit persisted under a high-fat diet, yet obesity restriction was achieved at the cost of compromised physical endurance. Thus, sarcolemmal KATP channels govern muscle energy economy, and their down-regulation in a tissue-specific manner could present an anti-obesity strategy by rendering muscle increasingly thermogenic at rest and less fuel efficient during exercise.
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影响因子：
4.8
作者：
Abraham, MR;Selivanov, VA;Terzic, A
通讯作者：
Terzic, A
影响因子：
7.7
作者：
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通讯作者：
Terzic, A
影响因子：
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作者：
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通讯作者：
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影响因子：
5.5
作者：
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通讯作者：
Renaud, Jean-Marc
DOI：
10.1152/ajpcell.2000.279.5.c1351
发表时间：
2000-11-01
影响因子：
5.5
作者：
Gong, B;Miki, T;Renaud, JM
通讯作者：
Renaud, JM