Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective.
Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective.
复制标题
研究阿尔茨海默病和帕金森病的动物模型：历史视角。
DOI：
10.1002/ame2.12209
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发表时间：
2022-03
影响因子：
3.7
通讯作者：
Tare M
中科院分区：
文献类型：
--
作者：
Banerjee R;Rai A;Iyer SM;Narwal S;Tare M
阿尔茨海默病和帕金森病是全球最普遍和最致残的两种神经退行性疾病。这两种疾病都是蛋白质病，虽然偶尔会遗传，但本质上主要是散发性的。虽然我们对这两种疾病的认识取得了重大进展，但还远远没有完成，无论是诊断还是目前的治疗和康复实践都没有足够的帮助。动物模型在历史上已被用作新疗法的试验床，并且仍然是药理学研究中有价值的辅助手段。这篇综述记录了阿尔茨海默病和帕金森病背景下这些模型的发展，并强调了在研究非人类生物体中两种人类特异性条件时的范式转变。神经元细胞中的细胞和分子变化可诱导蛋白质病，导致阿尔茨海默病和/或帕金森病（分别为AD和PD）。AD和PD都以由于细胞死亡导致的神经元损失为标志，并导致患者的认知丧失和运动受损。这篇综述讨论了AD和PD的病因学的历史观点已知的这些疾病。
Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally. Both are proteinopathic conditions and while occasionally inherited, are largely sporadic in nature. Although the advances in our understanding of the two have been significant, they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful. Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research. This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease, and highlights the shifting paradigms in studying two human‐specific conditions in non‐human organisms. Cellular and molecular changes in neuronal cells may induce proteinopathies, leading to Alzheimer's and/or Parkinson's diseases (AD and PD respectively). Both AD and PD are marked by the loss of neurons due to cell death and result in the loss of cognition and impaired movement of patients. This review discusses the etiology of AD and PD in terms of historical perspectives known for these diseases.
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影响因子：
16.8
作者：
Crotti A;Glass CK
通讯作者：
Glass CK
DOI：
10.1155/2017/2412486
发表时间：
2017
期刊：
Parkinson's disease
影响因子：
--
作者：
Bouhouche A;Tibar H;Ben El Haj R;El Bayad K;Razine R;Tazrout S;Skalli A;Bouslam N;Elouardi L;Benomar A;Yahyaoui M;Regragui W
通讯作者：
Regragui W
DOI：
10.1016/0169-328x(94)90029-9
发表时间：
1994-03-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
BLANCHARD, V;RAISMANVOZARI, R;AGID, Y
通讯作者：
AGID, Y
影响因子：
4.8
作者：
Bischof, Gerard N.;Endepols, Heike;Drzezga, Alexander
通讯作者：
Drzezga, Alexander
影响因子：
7.3
作者：
Austin, P. J.;Betts, M. J.;Duty, S.
通讯作者：
Duty, S.