Efficacy of One-Year Treatment with Aflibercept for Diabetic Macular Edema with Practical Protocol.
Efficacy of One-Year Treatment with Aflibercept for Diabetic Macular Edema with Practical Protocol.
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DOI：
10.1155/2017/7879691
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发表时间：
2017
影响因子：
--
通讯作者：
Yamamoto S
中科院分区：
文献类型：
--
作者：
Kaiho T;Oshitari T;Tatsumi T;Takatsuna Y;Arai M;Shimizu N;Sato E;Baba T;Yamamoto S
本研究的目的是确定根据实际方案，通过玻璃体内注射阿柏西普 (IVA) 治疗糖尿病性黄斑水肿 (DME) 一年的疗效。对 43 名诊断为 DME 并接受 IVA 治疗的患者的 51 只眼睛的医疗记录进行了审查。在基线以及 IVA 后 1、3、6 和 12 个月时测量最佳矫正视力 (BCVA) 和中央黄斑厚度 (CMT)。 IVA 注射的平均次数为 3.8 ± 2.4。 IVA 后所有随访时间的平均 BCVA 均显着改善，CMT 更薄 (P < 0.05)。浆液性视网膜脱离 (SRD) 眼的最佳矫正视力 (BCVA) 优于无 SRD 眼 (P < 0.01)。基线时和 IVA 后 12 个月时，光感受器外节 (PROS) 长度与 BCVA 之间存在显着相关性 (P < 0.05)。治疗一年后，较少次数的 IVA 注射可显着改善 DME 眼的 BCVA 和 CMT。 IVA 在 SRD+ 组中比在 SRD− 组中更有效。 PROS 长度可能是 IVA 治疗 DME 一年后视力结果的预测标记 (IRB#2272)。
The purpose of this study was to determine the efficacy of one-year treatment of diabetic macular edema (DME) with intravitreal aflibercept (IVA) injections on a practical protocol. The medical records of 51 eyes of 43 patients who were diagnosed with DME and had received IVA treatments were reviewed. The best-corrected visual acuity (BCVA) and the central macular thickness (CMT) were measured at the baseline and at 1, 3, 6, and 12 months after the IVA. The mean number of IVA injections was 3.8 ± 2.4. The mean BCVA was significantly better and the CMT was thinner after the IVA at all follow-up times (P < 0.05). The BCVA was better in eyes with a serous retinal detachment (SRD) than without a SRD (P < 0.01). There was a significant correlation between the photoreceptor outer segment (PROS) length and BCVA at the baseline and at 12 months after the IVA (P < 0.05). A fewer number of IVA injections significantly improved the BCVA and the CMT in eyes with DME after one-year treatment. IVA was more effective in the SRD+ group than in the SRD− group. The PROS length may be a predictive marker for visual outcomes after one-year treatment with IVA for DME (IRB#2272).
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影响因子：
4.4
作者：
Giocanti-Auregan, Audrey;Hrarat, Linda;Fajnkuchen, Franck
通讯作者：
Fajnkuchen, Franck
DOI：
10.1097/iae.0b013e3181bd2c5a
发表时间：
2010-01
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Forooghian F;Stetson PF;Meyer SA;Chew EY;Wong WT;Cukras C;Meyerle CB;Ferris FL 3rd
通讯作者：
Ferris FL 3rd
影响因子：
13.7
作者：
Do, Diana V.;Quan Dong Nguyen;Heier, Jeff S.
通讯作者：
Heier, Jeff S.
影响因子：
4.2
作者：
Patrao, Namritha V.;Antao, Sheelah;Rajendram, Ranjan
通讯作者：
Rajendram, Ranjan
DOI：
10.1097/iae.0000000000000770
发表时间：
2016-03-01
影响因子：
3.3
作者：
Seo, Kyung Hoon;Yu, Seung-Young;Kwak, Hyung Woo
通讯作者：
Kwak, Hyung Woo