Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study.
Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study.
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DOI：
10.1016/j.jalz.2014.03.009
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
ADAPT-FS Research Group
中科院分区：
文献类型：
--
作者：
ADAPT-FS Research Group
阿尔茨海默病抗炎预防试验(Adapt)和后续研究(Adapt-FS)检测了萘普生和塞来昔布对老年人认知的影响。我们在此报告描述认知评估测试分数轨迹的结果。2356名参与者在2001-2004年间完成了基线和至少一次后续认知评估。研究治疗在2004年停止，但参与者被跟踪到2007年。2010-2011年对1537名参与者进行了重新评估。结果包括在Adapt中每年进行7次面对面的认知评估，其中3次在Adapt结束时通过电话进行，并在Adapt-FS中再次进行。随着时间的推移，治疗组在任何适应认知测量、全球合成或电话重新评估的适应-FS中的三种认知测量上没有重要差异。使用萘普生或塞来昔布治疗1-3年并不能预防有AD家族史的老年人的认知能力下降。
The Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) and follow-up study (ADAPT-FS) examined effects of naproxen and celecoxib on cognition in the elderly. We report here results describing trajectories of cognitive evaluation test scores. 2356 participants completed baseline and at least one follow-up cognitive evaluation between 2001-2004. Study treatments were discontinued in 2004, but participants were followed until 2007. 1537 participants were re-evaluated in 2010-2011. Outcomes include seven cognitive evaluations administered yearly in-person in ADAPT and three of these evaluations that were administered by telephone near the end of ADAPT and again in ADAPT-FS. There were no important differences over time by treatment group on any ADAPT cognitive measure, a global composite, or the three cognitive measures re-assessed in ADAPT-FS by telephone. Treatment for 1 – 3 years with naproxen or celecoxib did not protect against cognitive decline in older adults with a family history of AD.
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DOI：
10.1111/j.1532-5415.1996.tb02932.x
发表时间：
1996-09-01
影响因子：
6.3
作者：
Rozzini, R;Ferrucci, L;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
--
作者：
Martin, Barbara K.;Szekely, Christine;Mullan, Michael
通讯作者：
Mullan, Michael
影响因子：
4
作者：
Bertozzi, B;Barbisoni, P;Trabucchi, M
通讯作者：
Trabucchi, M
影响因子：
4.2
作者：
Jonker, C;Comijs, HC;Smit, JH
通讯作者：
Smit, JH
影响因子：
5.7
作者：
Grodstein, Francine;Skarupski, Kimberly A.;Evans, Denis A.
通讯作者：
Evans, Denis A.