Role of CD44 isoforms in epithelial-mesenchymal plasticity and metastasis.
Role of CD44 isoforms in epithelial-mesenchymal plasticity and metastasis.
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DOI：
10.1007/s10585-022-10146-x
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发表时间：
2022-06
影响因子：
4
通讯作者：
Dhawan, Punita
中科院分区：
文献类型：
--
作者：
Primeaux, Mark;Gowrikumar, Saiprasad;Dhawan, Punita
细胞可塑性是癌症进展、转移和耐药性的核心。癌症中的干细胞和上皮-间充质可塑性是代表癌细胞选择和适应正常发育程序以促进存活和扩张的能力的概念。癌症干细胞模型指出，具有干细胞样特性的一小部分癌细胞负责驱动肿瘤发生和转移，同时保持对常见化疗药物的特别抗性。上皮-间充质可塑性描述了癌细胞在上皮和间充质表型之间转变的能力，其驱动侵袭和转移。最近的研究支持存在稳定的上皮/间充质杂交表型，其代表具有癌症干细胞特征的高度可塑性状态。细胞粘附分子CD 44是广泛接受的癌症干细胞的标志物，并且它位于调节干细胞和上皮-间充质可塑性的信号网络之间的功能交叉点。CD 44表达是复杂的，选择性剪接产生许多同种型。有趣的是，不仅在癌症中上皮和间充质表型之间的转变期间同种型表达模式发生变化，而且这些同种型对细胞行为具有不同的影响，包括促进转移和干性。CD 44在调节上皮-间充质可塑性和干细胞性的信号通路的下游和上游的作用使该蛋白成为进一步研究和治疗干预的有价值的靶标。
Cellular plasticity lies at the core of cancer progression, metastasis, and resistance to treatment. Stemness and epithelial-mesenchymal plasticity in cancer are concepts that represent a cancer cell’s ability to coopt and adapt normal developmental programs to promote survival and expansion. The cancer stem cell model states that a small subset of cancer cells with stem cell-like properties are responsible for driving tumorigenesis and metastasis while remaining especially resistant to common chemotherapeutic drugs. Epithelial-mesenchymal plasticity describes a cancer cell’s ability to transition between epithelial and mesenchymal phenotypes which drives invasion and metastasis. Recent research supports the existence of stable epithelial/mesenchymal hybrid phenotypes which represent highly plastic states with cancer stem cell characteristics. The cell adhesion molecule CD44 is a widely accepted marker for cancer stem cells, and it lies at a functional intersection between signaling networks regulating both stemness and epithelial-mesenchymal plasticity. CD44 expression is complex, with alternative splicing producing many isoforms. Interestingly, not only does the pattern of isoform expression change during transitions between epithelial and mesenchymal phenotypes in cancer, but these isoforms have distinct effects on cell behavior including the promotion of metastasis and stemness. The role of CD44 both downstream and upstream of signaling pathways regulating epithelial-mesenchymal plasticity and stemness make this protein a valuable target for further research and therapeutic intervention.
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影响因子：
11.2
作者：
Chaffer, Christine L.;Brennan, Janelle P.;Williams, Elizabeth D.
通讯作者：
Williams, Elizabeth D.
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
TGF-β1通过诱导PCBP1降解和CD44选择性剪接促进前列腺癌细胞的上皮间质转化和干性
影响因子：
8
作者：
Chen, Qi;Gu, Meng;Wang, Zhong
通讯作者：
Wang, Zhong
影响因子：
4
作者：
Bhattacharya, Rahul;Mitra, Tulika;Roy, Sib Sankar
通讯作者：
Roy, Sib Sankar
在可塑性和杂化E/M状态下，上皮到间质转变。
影响因子：
3.9
作者：
Bornes L;Belthier G;van Rheenen J
通讯作者：
van Rheenen J