Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification.
Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification.
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DOI：
10.1016/j.bioactmat.2021.06.035
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发表时间：
2022-03
影响因子：
18.9
通讯作者：
He B
中科院分区：
文献类型：
--
作者：
Mei H;Cai S;Huang D;Gao H;Cao J;He B
无载体纳米药物具有载药能力强、制备方法简单、可提供“多功能平台”等特点，近年来得到了长足的发展。然而，无载体纳米药物的天然缺陷限制了其在整个体内旅程中的递送和释放行为，这显著地损害了治疗功效并阻碍了其在癌症治疗中的进一步发展。在这篇综述中，我们总结并讨论了最近增强无载体纳米药物的药物递送和释放以改善癌症治疗的策略，包括优化固有的物理化学性质和外部修饰。最后，讨论了无载体纳米药物面临的挑战，并对其应用前景进行了展望。我们希望这篇综述能为合理设计更有效的无载体纳米药物提供建设性的信息，以促进治疗。无载体纳米药物在克服体内过程中的缺陷方面取得了很大的进展。本文系统地总结了近年来无载体纳米药物的释药策略，包括优化纳米药物的内在物理化学性质和外部修饰。综述了近年来无载体纳米药物在增强药物释放方面的研究进展。总结了优化其内在物理化学性质和外部改性的策略。无载体纳米药物的未来前景和挑战进行了讨论。
The considerable development of carrier-free nanodrugs has been achieved due to their high drug-loading capability, simple preparation method, and offering “all-in-one” functional platform features. However, the native defects of carrier-free nanodrugs limit their delivery and release behavior throughout the in vivo journey, which significantly compromise the therapeutic efficacy and hinder their further development in cancer treatment. In this review, we summarized and discussed the recent strategies to enhance drug delivery and release of carrier-free nanodrugs for improved cancer therapy, including optimizing the intrinsic physicochemical properties and external modification. Finally, the corresponding challenges that carrier-free nanodrugs faced are discussed and the future perspectives for its application are presented. We hope this review will provide constructive information for the rational design of more effective carrier-free nanodrugs to advance therapeutic treatment. Great enhancement of carrier-free nanodrugs has been achieved to overcome the defects during the in vivo journey. This review has systemically summarized the recent strategies to enhance drug delivery and release of carrier-free nanodrugs, including optimizing the intrinsic physicochemical properties and external modification. Recent progresses on carrier-free nanodrugs for enhancing drug delivery and release are summarized. Strategies of optimizing the intrinsic physicochemical properties and external modification are summarized. Future perspectives and challenges of carrier-free nanodrugs are discussed.
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影响因子：
10
作者：
Cheng C;Sui B;Wang M;Hu X;Shi S;Xu P
通讯作者：
Xu P
影响因子：
3.7
作者：
Fournier, E;Dufresne, MH;Leroux, JC
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Leroux, JC
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38.3
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通讯作者：
Li S
影响因子：
9.5
作者：
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通讯作者：
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