Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy.
Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy.
复制标题
DOI：
10.1038/nnano.2014.208
复制
发表时间：
2014-11
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
作者：
在设计药物载体时，药物与载体的比例是一个重要的考虑因素，因为使用大量的载体可能会导致由载体的不良代谢和消除引起的毒性。然而，如果药物和载体都具有治疗效果，这些问题就不那么令人担忧了。（-）-表没食子儿茶素-3-O-没食子酸酯（EGCG）是绿色茶的主要成分，已被证明具有抗癌作用、抗HIV作用、神经保护作用、DNA保护作用等。MNC是通过低聚EGCG与抗癌蛋白赫赛汀复合形成核，然后聚（乙二醇）-EGCG复合形成壳而获得的。当注射到小鼠体内时，负载赫赛汀的MNC显示出更好的肿瘤选择性和生长减少，以及比游离赫赛汀更长的血液半衰期。
In designing drug carriers, the drug-to-carrier ratio is an important consideration because using high quantities of carriers can cause toxicity resulting from poor metabolism and elimination of the carriers. However, these issues would be of less concern if both the drug and carrier possess therapeutic effects. (-)-Epigallocatechin-3-O-gallate (EGCG), which is a major ingredient of green tea, has been shown to possess anticancer effects, anti-HIV effects, neuroprotective effects, DNA-protective effects, etc. Here we show that sequential self-assembly of the EGCG derivative with anticancer proteins forms stable micellar nanocomplexes (MNCs), which have greater anticancer effects in vitro and in vivo than the free protein. The MNC is obtained by complexation of oligomerized EGCG with the anticancer protein, Herceptin, to form the core, followed by complexation of poly(ethylene glycol)-EGCG to form the shell. When injected into mice, the Herceptin-loaded MNC showed better tumour selectivity and growth reduction, and longer blood-half-life than free Herceptin.
登录
查看更多内容
影响因子：
6.2
作者：
Jöbstl, E;O'Connell, J;Williamson, MP
通讯作者：
Williamson, MP
影响因子：
3.1
作者：
Musacchio, Tiziana;Torchilin, Vladimir P.
通讯作者：
Torchilin, Vladimir P.
影响因子：
--
作者：
Li, Shenwei;Hattori, Toshio;Kodama, Eiichi N.
通讯作者：
Kodama, Eiichi N.
影响因子：
4.9
作者：
Kim D;Gao ZG;Lee ES;Bae YH
通讯作者：
Bae YH
影响因子：
6.2
作者：
Chung, JE;Kurisawa, M;Kobayashi, S
通讯作者：
Kobayashi, S