Body mass index ≥23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report.
Body mass index ≥23 is a risk factor for insulin resistance and diabetes in Japanese people: A brief report.
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DOI：
10.1371/journal.pone.0201052
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Yamamoto K
中科院分区：
文献类型：
--
作者：
Okura T;Nakamura R;Fujioka Y;Kawamoto-Kitao S;Ito Y;Matsumoto K;Shoji K;Sumi K;Matsuzawa K;Izawa S;Ueta E;Kato M;Imamura T;Taniguchi SI;Yamamoto K
建议体重指数≥23的亚裔美国人筛查未确诊的2型糖尿病。然而，预测日本人患糖尿病风险的最佳体重指数临界值尚不清楚。本研究的目的是确定预测日本人群胰岛素抵抗和糖尿病的最佳体重指数临界值。本研究分为临床调查和回顾性观察调查两部分。在研究的临床部分，58名参与者（26名2型糖尿病患者和32名非糖尿病患者）接受了高胰岛素-血糖钳夹，测量了他们的葡萄糖处置率。在研究的回顾部分，研究人员分析了鸟取县88305人的医疗检查数据，以寻找糖尿病的临床证据。确定预测胰岛素抵抗和糖尿病的最佳BMI分值。在钳形研究中，预测非糖尿病患者胰岛素抵抗的最佳体重指数临界值为22.7。所有2型糖尿病患者均为胰岛素抵抗，预测严重胰岛素抵抗的最佳体重指数临界值为26.2。当2型糖尿病患者和非糖尿病患者的数据结合在一起时，预测胰岛素抵抗的最佳体重指数临界值为23.5。对88305份体检记录的分析得出预测糖尿病的最佳体重指数临界值为23.6。这些结果表明，在日本人群中，体重指数≥23是胰岛素抵抗和糖尿病的危险因素。
Screening for undiagnosed type 2 diabetes mellitus is recommended for Asian Americans with a body mass index ≥23. However, the optimal body mass index cut-off score for predicting the risk of diabetes mellitus in Japanese people is not well known. The aim of this study was to determine the best body mass index cut-off score for predicting insulin resistance and diabetes mellitus in the Japanese population. This study had two parts, a clinical investigation and a retrospective observational investigation. In the clinical part of the study, 58 participants (26 with type 2 diabetes mellitus and 32 non-diabetics) underwent a hyperinsulinemic-euglycemic clamp from which their glucose disposal rate was measured. For the retrospective part of the study, medical check-up data from 88,305 people in the Tottori Prefecture were analyzed for clinical evidence of diabetes mellitus. The optimal BMI cut-off scores for prediction of insulin resistance and diabetes mellitus were determined. In the clamp study, the optimal body mass index cut-off score to predict insulin resistance in non-diabetic patients was 22.7. All participants with type 2 diabetes mellitus were insulin resistant, and the optimal body mass index cut-off score for prediction of severe insulin resistance was 26.2. When the data from the type 2 diabetic and the non-diabetic participants were combined, the optimal body mass index cut-off score for prediction of insulin resistance was 23.5. Analysis of 88,305 medical check-up records yielded an optimal body mass index cut-off score for prediction of diabetes mellitus of 23.6. These results suggest that having a body mass index ≥23 is a risk factor for insulin resistance and diabetes mellitus in the Japanese population.
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影响因子：
4.3
作者：
Okura T;Ueta E;Nakamura R;Fujioka Y;Sumi K;Matsumoto K;Shoji K;Matsuzawa K;Izawa S;Nomi Y;Mihara H;Otsuka Y;Kato M;Taniguchi SI;Yamamoto K
通讯作者：
Yamamoto K
影响因子：
16.2
作者：
Hsu WC;Araneta MR;Kanaya AM;Chiang JL;Fujimoto W
通讯作者：
Fujimoto W
影响因子：
5.1
作者：
Kawamori, R;Matsuhisa, M;Yamasaki, Y
通讯作者：
Yamasaki, Y
影响因子：
3.3
作者：
Matsuzawa, Y;Nakamura, T;Nagai, M
通讯作者：
Nagai, M
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC