Nanofibers/PVA Blended Nano Fibre Matrix for Nervous Tissue Regeneration
Nanofibers/PVA Blended Nano Fibre Matrix for Nervous Tissue Regeneration
复制标题
用于神经组织再生的纳米纤维/PVA 混合纳米纤维基质
DOI：
10.4028/www.scientific.net/amm.404.95
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Shanxiao Wu
中科院分区：
文献类型：
--
作者：
Ping Zhang;Shanxiao Wu
静电纺丝产生的纳米纤维代表了一类新的有前途的支架，以支持神经再生。在这里，我们发现，壳聚糖（CS）与聚（乙烯醇）（PVA）的混合溶液是适当的静电纺丝时，它们形成导电的，非结构化的流体显示塑性，而不是弹性，在本体和界面处。然后，我们研究了利用静电纺丝纳米纤维来操纵与神经组织再生相关的生物过程，包括干细胞分化，指导神经突延伸和周围神经损伤治疗。本文的主要目的是为研究神经突起在新型纳米纤维支架上的生长机制以及优化用于修复周围神经损伤的纳米纤维支架和导管提供有价值的方法。
Nanofibers produced by electrospinning represent a new class of promising scaffolds to support nerve regeneration. Here, we found that the blended solutions of chitosan (CS) with Poly (vinyl alcohol) (PVA) are appropriate for electrospinning when they form conductive, unstructured fluids displaying plasticity, rather than elasticity, in the bulk and at the interface. We then studied that utilize electrospun nanofibers to manipulate biological processes relevant to nervous tissue regeneration, including stem cell differentiation, guidance of neurite extension, and peripheral nerve injury treatments. The main objective of this article is to provide valuable methods for investigating the mechanisms of neurite growth on novel nanofibrous scaffolds and optimization of the nanofiber scaffolds and conduits for repairing peripheral nerve injuries.
影响因子：
3.1
作者：
Chew, S. Y.;Wen, Y.;Leong, K. W.
通讯作者：
Leong, K. W.