Design of DNA-Cleaving Agents
Design of DNA-Cleaving Agents
复制标题
DNA 切割剂的设计
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. Nakatani
中科院分区：
文献类型：
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作者：
I. Saito;K. Nakatani
本文综述了我们实验室最近发展起来的人工序列特异性DNA切割器的分子设计。这些药物包括：模拟天然抗肿瘤抗生素的DNA切割器，如烯二炔抗生素、博莱霉素和卡普里霉素A3。还描述了光化学DNA裂解分子的设计。它们是：1)非选择性DNA切割酶，2)胸腺嘧啶选择性DNA切割酶，3)光Fenton试剂，4)光诱导DNA烷基化试剂，v)光诱导电子转移DNA切割酶。描述了这些DNA裂解剂的范围和局限性，特别强调了设计新型序列特异性DNA裂解器的概念和策略，以及它们DNA裂解的机制方面。
The review focuses on the molecular design of artificial sequence-specific DNA-cleavers which have recently been developed in our laboratories. These include: DNA cleavers mimicking natural antitumor antibiotic like enediyne antibiotics, bleomycins, and kapurimycin A3. The design of photochemical DNA-cleaving molecules is also described. These are classified as: i) nonselective DNA cleavers, ii) thymine selective DNA cleavers, iii) photo-Fenton reagents, iv) photoinducible DNA alkylating agents, and v) DNA cleavers via photoinduced electrontransfer. The scope and limitation of these DNA-cleaving agents are described with a special emphasis on the concept and strategy for designing novel sequence-specific DNA cleavers, as well as on the mechanistic aspects of their DNA cleavage.
影响因子：
56.9
作者：
DERVAN, PB
通讯作者：
DERVAN, PB