Microbleeds and silent brain infarctions are differently associated with cognitive dysfunction in patients with advanced periventricular leukoaraiosis.
Microbleeds and silent brain infarctions are differently associated with cognitive dysfunction in patients with advanced periventricular leukoaraiosis.
复制标题
微出血和无症状脑梗塞与晚期脑室周围白质疏松症患者的认知功能障碍存在不同的相关性。
DOI：
10.7150/ijms.6430
复制
发表时间：
2013
影响因子：
3.6
通讯作者：
Liu XY
中科院分区：
文献类型：
--
作者：
Fang M;Feng C;Xu Y;Hua T;Jin AP;Liu XY
脑白质疏松、微出血和无症状脑梗塞是小血管疾病的表型。脑白质疏松症是最常见的，晚期脑室周围脑白质疏松症被认为是认知功能障碍的强烈预测因素。微出血和无症状脑梗塞有时与脑白质疏松症并存。本研究旨在分析微出血和无症状脑梗死对晚期脑室周围白质疏松症患者认知功能的影响。 227例晚期脑室周围白质疏松症患者分为对照组、MB组、SBI组和MB&SBI组。评估了微出血和无症状脑梗塞的存在和位置。进行了简易精神状态检查、蒙特利尔认知评估、画钟测试和言语流畅性测试。卡方检验和方差分析比较四组的特征，多元线性回归找出认知功能障碍的危险因素。 MB和MB&SBI组的所有四项测试的分数均较低，而SBI组仅时钟绘图测试和言语流利度测试的分数低于对照组。年龄和微出血的存在是所有四项测试中得分较低的独立风险因素，而无声脑梗塞的存在是时钟绘图测试和言语流畅性测试中得分较低的唯一独立风险因素。脑叶微出血对认知功能的影响最为显着。 微出血和无症状脑梗死与晚期脑室周围白质疏松症患者的认知障碍存在不同的相关性。脑叶微出血的影响最为显着。
Leukoaraiosis, microbleeds, and silent brain infarctions are phenotypes of small vessel disease. Leukoaraiosis is the most prevalent, and advanced periventricular leukoaraiosis is regarded as a strong predictor of cognitive dysfunction. Microbleeds and silent brain infarctions sometimes coexist with leukoaraiosis. This study aims to analyze the effects of microbleeds and silent brain infarctions on cognitive function of patients with advanced periventricular leukoaraiosis. 227 patients with advanced periventricular leukoaraiosis were divided into control, MB, SBI, and MB&SBI groups. The presence and locations of microbleeds and silent brain infarctions were evaluated. Mini-Mental State Examination, Montreal Cognitive Assessment, Clock Drawing Test and Verbal Fluency Test were performed. Chi-square test and ANOVA to compare the characteristics of four groups, multiple linear regressions to identify the risk factors for cognitive dysfunction. The scores in all four tests were lower in the MB and MB&SBI groups while only the scores in Clock Drawing Test and Verbal Fluency Test were lower in the SBI group than in the control group. Age and the presence of microbleeds were independent risk factors for the lower scores in all four tests, whereas the presence of silent brain infarctions was the only independent risk factor for the lower scores in Clock Drawing Test and Verbal Fluency Test. Lobar microbleeds had the most significant effect on cognitive function. Microbleeds and silent brain infarctions were associated differently with cognitive impairment of patients with advanced periventricular leukoaraiosis. The effect of lobar microbleeds was the most significant.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
11.2
作者：
Dierksen, Gregory A.;Skehan, Maureen E.;Khan, Muhammad A.;Jeng, Jed;Nandigam, R. N. Kaveer;Becker, John A.;Kumar, Ashok;Neal, Krista L.;Betensky, Rebecca A.;Frosch, Matthew P.;Rosand, Jonathan;Johnson, Keith A.;Viswanathan, Anand;Salat, David H.;Greenberg, Steven M.
通讯作者：
Greenberg, Steven M.
影响因子：
8.3
作者：
van Dijk, Ewoud J.;Prins, Niels D.;Breteler, Monique M. B.
通讯作者：
Breteler, Monique M. B.
影响因子：
9.9
作者：
van Es, A. C. G. M.;van der Grond, J.;van Buchem, M. A.
通讯作者：
van Buchem, M. A.
影响因子：
5
作者：
Geerlings, Mirjam I.;Appelman, Auke P. A.;van der Graaf, Yolanda
通讯作者：
van der Graaf, Yolanda