Memory T follicular helper CD4 T cells.
Memory T follicular helper CD4 T cells.
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DOI：
10.3389/fimmu.2015.00016
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发表时间：
2015
影响因子：
7.3
通讯作者：
Ahmed R
中科院分区：
文献类型：
--
作者：
Hale JS;Ahmed R
滤泡辅助性T细胞（Tfh）是CD 4辅助性T细胞的亚群，其是产生和维持生殖中心反应以及产生长寿的体液免疫所必需的。这种特化的辅助性T细胞亚群通过表达CD 40配体、IL-21、IL-4和其他分子为同源B细胞提供帮助。Tfh细胞的特征在于它们表达趋化因子受体CXCR 5、表达转录抑制因子Bcl 6，以及它们迁移到卵泡和促进生发中心B细胞应答的能力。直到最近，仍不清楚Tfh细胞是否分化为记忆细胞，以及它们是否在记忆阶段维持Tfh定型。这篇综述将突出最近的几项研究，支持的想法Tfh-承诺的CD 4 T细胞在免疫应答的记忆阶段。这些发现的含义是，记忆Tfh细胞在重新激活后保留了其回忆其Tfh特异性效应子功能的能力，从而为B细胞应答提供帮助，并在引发和加强疫苗接种或在对感染的回忆应答期间发挥重要作用。将讨论用于区分Tfh效应细胞和记忆细胞的标记物，以及使用这些标记物的局限性。Tfh效应子和记忆产生、谱系维持和相对于其他T辅助谱系（Th 1、Th 2、Th 17等）的可塑性也将讨论。关于记忆Tfh细胞的维持和谱系稳定性与可塑性的持续发现将改善利用CD 4 T细胞记忆来调节初免和加强疫苗接种期间的抗体应答的策略。
T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and other molecules. Tfh cells are characterized by their expression of the chemokine receptor CXCR5, expression of the transcriptional repressor Bcl6, and their capacity to migrate to the follicle and promote germinal center B cell responses. Until recently, it remained unclear whether Tfh cells differentiated into memory cells and whether they maintain Tfh commitment at the memory phase. This review will highlight several recent studies that support the idea of Tfh-committed CD4 T cells at the memory stage of the immune response. The implication of these findings is that memory Tfh cells retain their capacity to recall their Tfh-specific effector functions upon reactivation to provide help for B cell responses and play an important role in prime and boost vaccination or during recall responses to infection. The markers that are useful for distinguishing Tfh effector and memory cells, as well as the limitations of using these markers will be discussed. Tfh effector and memory generation, lineage maintenance, and plasticity relative to other T helper lineages (Th1, Th2, Th17, etc.) will also be discussed. Ongoing discoveries regarding the maintenance and lineage stability versus plasticity of memory Tfh cells will improve strategies that utilize CD4 T cell memory to modulate antibody responses during prime and boost vaccination.
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DOI：
10.1084/jem.20120219
发表时间：
2012-09-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Liu X;Yan X;Zhong B;Nurieva RI;Wang A;Wang X;Martin-Orozco N;Wang Y;Chang SH;Esplugues E;Flavell RA;Tian Q;Dong C
通讯作者：
Dong C
影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.8
作者：
Crotty, S;Kersh, EN;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
4.4
作者：
Crotty, S;Felgner, P;Ahmed, R
通讯作者：
Ahmed, R