Autism spectrum disorders in the Stockholm Youth Cohort: design, prevalence and validity.
Autism spectrum disorders in the Stockholm Youth Cohort: design, prevalence and validity.
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DOI：
10.1371/journal.pone.0041280
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Magnusson C
中科院分区：
文献类型：
--
作者：
Idring S;Rai D;Dal H;Dalman C;Sturm H;Zander E;Lee BK;Serlachius E;Magnusson C
关于自闭症谱系障碍(ASD)患病率上升的报告，及其沉重的个人和社会负担，强调了需要进行方法上合理的研究，以探索其原因和后果。我们在这里介绍了一个大型跨代ASD研究资源的设计，以及基于人群的ASD患病率估计及其诊断有效性。斯德哥尔摩青年队列是一项记录-联系研究，涵盖了2001年至2007年居住在斯德哥尔摩县的所有0-17岁个人(N = 589,114)。自闭症病例(N = 5,100例)采用多来源方法确定，涉及自闭症诊断和护理的所有途径的登记，并根据并存的智力残疾进行分类。从国家和区域卫生和行政登记中检索到关于ASD潜在决定因素和后果的前瞻性记录信息。在一项全国性的双生子研究中，通过病例笔记审查和与共存病例的交叉验证来确认病例确证。2007年，自闭症在所有儿童和年轻人中的患病率为11.5‰(95%可信区间11.2-11.8)，42.6%(41.0-44.2)的病例记录了并存的智力残疾。我们发现96.0%(92.0-98.4)的病例记录与ASD的诊断一致，85.2%(66.2-95.8)的双胞胎确诊为ASD。这项当代研究的结果与最近报道的西方国家基于有效病例确定的约1%的患病率估计相符。鉴于瑞典登记册提供的大量信息，斯德哥尔摩青年队列是自闭症研究的重要资源。正在进行的工作，包括收集生物样本，将进一步丰富这项研究。
Reports of rising prevalence of autism spectrum disorders (ASD), along with their profound personal and societal burden, emphasize the need of methodologically sound studies to explore their causes and consequences. We here present the design of a large intergenerational resource for ASD research, along with population-based prevalence estimates of ASD and their diagnostic validity. The Stockholm Youth Cohort is a record-linkage study comprising all individuals aged 0–17 years, ever resident in Stockholm County in 2001–2007 (N = 589,114). ASD cases (N = 5,100) were identified using a multisource approach, involving registers covering all pathways to ASD diagnosis and care, and categorized according to co-morbid intellectual disability. Prospectively recorded information on potential determinants and consequences of ASD were retrieved from national and regional health and administrative registers. Case ascertainment was validated through case-note review, and cross validation with co-existing cases in a national twin study. The 2007 year prevalence of ASD in all children and young people was 11.5 per 1,000 (95% confidence interval 11.2–11.8), with a co-morbid intellectual disability recorded in 42.6% (41.0–44.2) of cases. We found 96.0% (92.0–98.4) of reviewed case-notes being consistent with a diagnosis of ASD, and confirmed ASD in 85.2% (66.2–95.8) of affected twins. Findings from this contemporary study accords with recently reported prevalence estimates from Western countries at around 1%, based on valid case ascertainment. The Stockholm Youth Cohort, in light of the availability of extensive information from Sweden's registers, constitutes an important resource for ASD research. On-going work, including collection of biological samples, will enrich the study further.
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影响因子：
10.5
作者：
Baron-Cohen, Simon;Scott, Fiona J.;Brayne, Carol
通讯作者：
Brayne, Carol
DOI：
10.1177/140349489001800209
发表时间：
1990-01-01
期刊：
SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE
影响因子：
--
作者：
CNATTINGIUS, S;ERICSON, A;KALLEN, B
通讯作者：
KALLEN, B
影响因子：
--
作者：
D'Onofrio, Brian M.;Singh, Amber L.;Iliadou, Anastasia;Lambe, Mats;Hultman, Christina M.;Grann, Martin;Neiderhiser, Jenae M.;Langstrom, Niklas;Lichtenstein, Paul
通讯作者：
Lichtenstein, Paul
影响因子：
4.5
作者：
Giarelli E;Wiggins LD;Rice CE;Levy SE;Kirby RS;Pinto-Martin J;Mandell D
通讯作者：
Mandell D
影响因子：
--
作者：
Hallmayer, Joachim;Cleveland, Sue;Torres, Andrea;Phillips, Jennifer;Cohen, Brianne;Torigoe, Tiffany;Miller, Janet;Fedele, Angie;Collins, Jack;Smith, Karen;Lotspeich, Linda;Croen, Lisa A.;Ozonoff, Sally;Lajonchere, Clara;Grether, Judith K.;Risch, Neil
通讯作者：
Risch, Neil