To predict the radiosensitivity of nasopharyngeal carcinoma using intravoxel incoherent motion MRI at 3.0 T.
To predict the radiosensitivity of nasopharyngeal carcinoma using intravoxel incoherent motion MRI at 3.0 T.
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使用 3.0 T 体素内不相干运动 MRI 预测鼻咽癌的放射敏感性
DOI：
10.18632/oncotarget.17367
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发表时间：
2017-08-08
期刊：
影响因子：
--
通讯作者：
Zhang SX
中科院分区：
文献类型：
--
作者：
Chen WB;Zhang B;Liang L;Dong YH;Cai GH;Liang CH;Lan BW;Zhang SX
为了研究内腔内不连贯运动（IVIM）MRI，以评估放射疗法对鼻咽癌（NPC）的敏感性。
在观察者和观察者之间的可重复性相对较好。 1）有效组的有效组显着高，而f的差异（18.79％±2.51 vs. 16.47％±1.51）和ADC（1.21×10-3 mm2/s±0.11 vs. 1.33×10-3 mm2/s±0.23）在两组之间无法达到统计学意义（p> 0.05）。
IVIM可能在评估NPC的放射敏感性方面有可能有用。
在T3或T4的阶段，有60名患者（20名女性，27-83岁，平均年龄，52岁）被纳入了42例NPC。的参数IVIM包括灌注分数（F），纯分子差异（D）和明显的扩散系数（ADC）被用来评估两组。
To investigate intravoxel incoherent motion (IVIM) MRI for evaluating the sensitivity of radiotherapy on nasopharyngeal carcinoma (NPC). The reproducibility between intra-observer and inter-observer was relatively good. D (0.72×10−3 mm2/s±0.14 vs. 0.54×10−3 mm2/s±0.23; P < 0.001) and D* (157.92×10−3 mm2/s±15.21 vs. 120.36×10−3 mm2/s±10.22; P < 0.0001) were significantly higher in effective group than poor-effective group, whereas the difference of f (18.79%±2.51 vs. 16.47%±1.51) and ADC (1.21×10−3 mm2/s±0.11 vs. 1.33×10−3 mm2/s±0.23) could not reach statistical significant between the 2 groups (P > 0.05). IVIM may be potentially useful in assessing the radiosensitivity of NPC. The higher D value combining with higher D* value might indicate the more radiosensitive of NPC, and increased D* might reflect increased blood vessel generation and parenchymal perfusion in NPC. Sixty consecutive patients (20 female, range, 27-83 years, mean age, 52 years) newly diagnosed NPC in the stage of T3 or T4 were enrolled. Forty-two of them were divided into effective group clinically after a standard radiotherapy according to the RECIST criteria. IVIM with 13 b-values (range, 0-800 s/mm2) and general MRI were performed at 3.0T MR scanner before and after radiotherapy. The parameters of IVIM including perfusion fraction (f), perfusion-related diffusion (D*), pure molecular diffusion (D) and apparent diffusion coefficient (ADC) were calculated. Two radiologists major in MRI diagnose analyzed all images independently and placed regions of interest (ROIs). Intra-class correlation coefficient (ICC) was used to evaluate intra-observer and inter-observer agreement. And Mann–Whitney test was used to assess the differences between the two groups.
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DOI：
10.1158/1078-0432.ccr-08-1287
发表时间：
2009-02-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Kim S;Loevner L;Quon H;Sherman E;Weinstein G;Kilger A;Poptani H
通讯作者：
Poptani H
影响因子：
50.3
作者：
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Jain RK
影响因子：
19.7
作者：
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通讯作者：
Rahmouni, Alain
影响因子：
4.4
作者：
Qi, Jing;Olsen, Nancy J.;Park, Jane H.
通讯作者：
Park, Jane H.
影响因子：
5.7
作者：
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通讯作者：
Overgaard, J