Attenuated arteriolar dilator responses to calcium in genetically hypertensive rats.
Attenuated arteriolar dilator responses to calcium in genetically hypertensive rats.
复制标题
遗传性高血压大鼠的小动脉扩张器对钙的反应减弱。
DOI：
10.1161/01.hyp.6.5.647
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Overbeck,HW
中科院分区：
文献类型：
--
作者：
Overbeck,HW
在氯醛糖-戊巴比妥麻醉下，研究了14只遗传性高血压（GH）新西兰品系大鼠和16只体重和年龄匹配的血压正常的亲本品系对照大鼠对钙的血管反应。将钙（氯化物或葡萄糖酸盐）的等渗溶液经动脉内输注至后肢血管床，该血管床经血管分离、神经支配和泵灌注（血液，1 ml/min）。肢体血浆钙浓度升高至30 mEq/L时，肢体血管阻力降低，无血管收缩证据。在GH大鼠中，与年龄匹配的对照组相比，肢体血管阻力对肢体血浆钙浓度增加3.6至10.8 mEq/L的反应显著减弱（p <0.02）。当GH的反应与体重匹配的对照相比时，在Ca 2+增量为10.8 mEq/L时，类似的衰减趋势达到显著性（p <0.02）。在其他八只GH大鼠中，我们测量了总血清钙浓度，发现它们降低了（4.94 +/- 0.08 mEq/升），特别是与八只不相关的Wistar品系大鼠的值（5.42 +/- 0.04 mEq/升; p小于0.05）相比。这些实验提供的证据表明，在生理范围内，钙放松小动脉平滑肌在大鼠和这种血管舒张在遗传性高血压大鼠减弱。因此，较低的血清钙水平和减弱的钙反应可能有助于这些大鼠外周血管阻力升高和高血压。
Vascular responses to calcium were studied in 14 genetically hypertensive (GH) rats of the New Zealand strain and 16 weight- and age-matched normotensive parent strain control rats under chloralose-pentobarbital anesthesia. Calcium (chloride or gluconate) in an isosmolar solution was infused intraarterially into the hindlimb vascular bed which was vascularly isolated, innervated, and pump-perfused (blood, 1 ml/min). Increases in limb plasma calcium concentrations up to 30 mEq/liter decreased limb vascular resistance, with no evidence for vasoconstriction. In GH rats decreases in limb vascular resistance in response to increments in limb plasma calcium concentrations of 3.6 to 10.8 mEq/liter were significantly (p less than 0.02) attenuated compared to age-matched controls. When responses in GH were compared to weight-matched controls, similar trends toward attenuation reached significance (p less than 0.02) at Ca2+ increments of 10.8 mEq/liter. In eight other GH rats, we measured total serum calcium concentrations and found them reduced (4.94 +/- 0.08 mEq/liter), especially as compared to values in eight rats of an unrelated Wistar strain (5.42 +/- 0.04 mEq/liter; p less than 0.05). These experiments provide evidence that, over physiological ranges, calcium relaxes arteriolar smooth muscle in rats and that this vasodilation is attenuated in genetically hypertensive rats. Thus, both the lower serum levels of calcium and the attenuated responses to calcium may contribute to the elevated peripheral vascular resistance and hypertension in these rats.
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影响因子：
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作者：
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