Small molecule-gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells.
Small molecule-gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells.
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DOI：
10.1002/smll.201200333
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发表时间：
2012-09-24
期刊：
影响因子：
13.3
通讯作者：
El-Sayed, Mostafa A.
中科院分区：
文献类型：
--
作者：
Dreaden, Erik C.;Mwakwari, Sandra C.;Austin, Lauren A.;Kieffer, Matthew J.;Oyelere, Adegboyega K.;El-Sayed, Mostafa A.
金纳米粒子在癌症的诊断和治疗中显示出巨大的实用性和多功能性。[1]这些结构不仅可以作为靶向药物输送载体，[2]它们还可以作为近红外(NIR)激光光热肿瘤消融术的造影剂[3]，以及在其他生物医学诊断[1a，4]和治疗[5]应用中的平台。单核巨噬细胞系统(MPS)对循环中纳米颗粒的摄取和清除是有效地将纳米结构输送到实体肿瘤的最大障碍之一，到目前为止，大多数肿瘤靶向策略都试图避开MPS并增加循环时间。在这里，我们表明，胶体金纳米棒(AuNRs)可以主动地靶向吞噬细胞，这些巨噬细胞表现出高的内在积聚和对实体瘤的渗透。在共培养条件下，大环内酯功能化的金纳米棒被优先传递给肿瘤相关巨噬细胞()，并选择性地诱导依赖的细胞毒作用。由于TAMs在循环中自由迁移，[7]绕过血脑屏障，[8]并广泛积聚/渗透到乳腺肿瘤中，[9]这些数据表明，巨噬细胞靶向的金纳米颗粒可以作为靶向癌症治疗的有前景的候选药物。
Gold nanoparticles have demonstrated tremendous utility and multifunctionality for the diagnosis and treatment of cancer.[1] Not only can these structures serve as targeted drug delivery vehicles,[2] they can also act as contrast agents for near-infrared (NIR) laser photothermal tumor ablation [3] and as platforms in a range of other biomedical diagnostic [1a, 4] and therapeutic [5] applications. The uptake and removal of circulating nanoparticles by the mononuclear phagocyte system (MPS),[6] represents one of the most significant impediments to the efficient delivery of nanoscale structures to solid tumors, and to-date, the majority of tumor-targeting strategies for nanoparticles attempt to evade the MPS and increase circulation time. Here, we show that colloidal gold nanorods (AuNRs) can be actively targeted towards phagocytic macrophages that exhibit high intrinsic accumulation and infiltration into solid tumors. Macrolide-functionalized gold nanorods were preferentially delivered to tumor-associated macrophage (TAM) cells and selectively induced TAM-dependent cytotoxicity towards breast cancer cells in co-culture. Because TAMs migrate freely in circulation,[7] bypass the blood–brain barrier,[8] and extensively accumulate/infiltrate into breast tumors,[9] these data show that macrophage-targeting gold nanoparticles can serve as promising candidates for targeted cancer therapy.
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DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
17.1
作者：
Bartneck, Matthias;Keul, Heidrun A.;Groll, Juergen
通讯作者：
Groll, Juergen
影响因子：
5.4
作者：
Alizadeh, Darya;Zhang, Leying;Hwang, Jungyeon;Schluep, Thomas;Badie, Behnam
通讯作者：
Badie, Behnam
DOI：
10.1158/1078-0432.ccr-10-3420
发表时间：
2011-09-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Daldrup-Link HE;Golovko D;Ruffell B;Denardo DG;Castaneda R;Ansari C;Rao J;Tikhomirov GA;Wendland MF;Corot C;Coussens LM
通讯作者：
Coussens LM
影响因子：
78.8
作者：
Jain, Rakesh K.;Stylianopoulos, Triantafyllos
通讯作者：
Stylianopoulos, Triantafyllos