Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas.
Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas.
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DOI：
10.1016/j.nano.2009.10.001
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发表时间：
2010-04
影响因子：
5.4
通讯作者：
Badie, Behnam
中科院分区：
文献类型：
--
作者：
Alizadeh, Darya;Zhang, Leying;Hwang, Jungyeon;Schluep, Thomas;Badie, Behnam
本研究的目的是评估基于环糊精的纳米颗粒（CDP-NP）摄取到小鼠胶质瘤模型中的机制。使用混合的体外培养系统，我们证明了CDP-NP优先被BV 2和N9小胶质细胞（MG）细胞相比，GL 261胶质瘤细胞。颅内（i.c.）GL 261胶质瘤证实了这些发现，并证明了肿瘤部位内和周围的巨噬细胞（MP）和MG对CDP-NP的主要摄取。有趣的是，在双侧i.c.携带CDP-NP的MG和MP能够迁移到对侧肿瘤。总之，这些研究更好地表征了i.c.肿瘤，并证明MP和MG可能潜在地用作恶性脑肿瘤的纳米颗粒药物载体。
The goal of this study was to evaluate the mechanism of cyclodextrin-based nanoparticle (CDP-NP) uptake into a murine glioma model. Using mixed in vitro culture systems, we demonstrated that CDP-NP was preferentially taken up by BV2 and N9 microglia (MG) cells as compared to GL261 glioma cells. Fluorescent microscopy and flow cytometry analysis of intracranial (i.c.) GL261 gliomas confirmed these findings and demonstrated a predominant CDP-NP uptake by macrophages (MP) and MG within and around the tumor site. Interestingly, in mice bearing bilateral i.c. tumor, MG and MP carrying CDP-NP were able to migrate to the contralateral tumors. In conclusion, these studies better characterize the cellular distribution of CDP-NP in i.c. tumors and demonstrate that MP and MG could potentially be used as nanoparticle drug carriers into malignant brain tumors.
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影响因子：
11.2
作者：
Hussain, S. Farzana;Kong, Ling-Yuan;Heimberger, Amy B.
通讯作者：
Heimberger, Amy B.
影响因子：
3.3
作者：
Badie, B;Bartley, B;Schartner, J
通讯作者：
Schartner, J
DOI：
10.1016/j.ejpb.2008.05.007
发表时间：
2008-10-01
影响因子：
4.9
作者：
Reimold, Isolde;Domke, Diana;Fricker, Gert
通讯作者：
Fricker, Gert
影响因子：
7.4
作者：
Hussain SF;Yang D;Suki D;Grimm E;Heimberger AB
通讯作者：
Heimberger AB
影响因子：
4.3
作者：
Jain, K K
通讯作者：
Jain, K K