The potential of tetrandrine as a protective agent for ischemic stroke.
The potential of tetrandrine as a protective agent for ischemic stroke.
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DOI：
10.3390/molecules16098020
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发表时间：
2011-09-16
期刊：
影响因子：
--
通讯作者：
Tseng SH
中科院分区：
文献类型：
--
作者：
Chen Y;Tsai YH;Tseng SH
卒中是导致死亡的主要原因之一，幸存者的严重发病率很高。减少卒中后组织损伤的治疗仍不令人满意，迫切需要制定有效的卒中治疗策略。缺血性卒中的病理生理机制复杂，涉及能量衰竭、离子稳态丧失、细胞内钙水平升高、血小板聚集、活性氧产生、血脑屏障破坏、炎症和白细胞浸润等多个过程。粉防己碱是一种双苄基异喹啉生物碱，具有抗炎、细胞保护等多种药理作用。此外，粉防己碱还被发现可以保护肝脏、心脏、小肠和大脑免受缺血/再灌注损伤。它是一种钙通道阻滞剂，可以抑制脂质过氧化，减少活性氧的产生，抑制细胞因子和炎症介质的产生，抑制中性粒细胞募集和血小板聚集，这些都是脑缺血/再灌注损伤中的破坏性因素。由于粉防己碱可以对抗这些重要的缺血性卒中的病理生理过程，因此有可能成为缺血性卒中的保护剂。
Stroke is one of the leading causes of mortality, with a high incidence of severe morbidity in survivors. The treatment to minimize tissue injury after stroke is still unsatisfactory and it is mandatory to develop effective treatment strategies for stroke. The pathophysiology of ischemic stroke is complex and involves many processes including energy failure, loss of ion homeostasis, increased intracellular calcium level, platelet aggregation, production of reactive oxygen species, disruption of blood brain barrier, and inflammation and leukocyte infiltration, etc. Tetrandrine, a bisbenzylisoquinoline alkaloid, has many pharmacologic effects including anti-inflammatory and cytoprotective effects. In addition, tetrandrine has been found to protect the liver, heart, small bowel and brain from ischemia/reperfusion injury. It is a calcium channel blocker, and can inhibit lipid peroxidation, reduce generation of reactive oxygen species, suppress the production of cytokines and inflammatory mediators, inhibit neutrophil recruitment and platelet aggregation, which are all devastating factors during ischemia/reperfusion injury of the brain. Because tetrandrine can counteract these important pathophysiological processes of ischemic stroke, it has the potential to be a protective agent for ischemic stroke.
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影响因子：
5.8
作者：
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通讯作者：
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作者：
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DOI：
10.1006/bbrc.1997.6057
发表时间：
1997-02-03
影响因子：
3.1
作者：
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通讯作者：
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