Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.
Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and infancy.
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DOI：
10.1038/s41467-022-32188-1
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发表时间：
2022-07-30
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
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作者：
需要进行研究来评估怀孕期间mRNA SARS-CoV-2疫苗接种的安全性和有效性，以及通过胎盘转移抗体为新生儿提供的保护水平。在这里，我们评估了mRNA疫苗产品和功能性抗SARS-CoV-2抗体在怀孕期间和婴儿早期在一个队列的20个人在怀孕后期接种的经胎盘转移。我们在分娩时的母体血液、胎盘组织或脐带血中没有发现mRNA疫苗产物的证据。然而，我们发现时间依赖性的有效转移的IgG和中和抗体的新生儿，持续在婴儿早期。此外，使用噬菌体免疫沉淀测序，我们发现了SARS-CoV-2刺突蛋白表位结合的疫苗特异性签名，该签名在妊娠期间经胎盘转移。怀孕期间接种疫苗的时机对于确保保护性抗体在婴儿早期经胎盘转移至关重要。怀孕的个体有更高的SARS-CoV-2相关发病率和死亡率的风险，但需要更多的研究来评估怀孕期间接种疫苗的安全性和有效性，以及为新生儿提供的保护水平。在这里，作者评估了mRNA疫苗产品和功能性SARS-CoV-2抗体在妊娠和婴儿早期的经胎盘转移。
Studies are needed to evaluate the safety and effectiveness of mRNA SARS-CoV-2 vaccination during pregnancy, and the levels of protection provided to their newborns through placental transfer of antibodies. Here, we evaluate the transplacental transfer of mRNA vaccine products and functional anti-SARS-CoV-2 antibodies during pregnancy and early infancy in a cohort of 20 individuals vaccinated during late pregnancy. We find no evidence of mRNA vaccine products in maternal blood, placenta tissue, or cord blood at delivery. However, we find time-dependent efficient transfer of IgG and neutralizing antibodies to the neonate that persists during early infancy. Additionally, using phage immunoprecipitation sequencing, we find a vaccine-specific signature of SARS-CoV-2 Spike protein epitope binding that is transplacentally transferred during pregnancy. Timing of vaccination during pregnancy is critical to ensure transplacental transfer of protective antibodies during early infancy. Pregnant individuals are at higher risk of SARS-CoV-2-related morbidity and mortality, yet more studies are needed to evaluate safety and efficacy of vaccination during pregnancy, and also the level of protection provided to the newborn. Here, the authors evaluate transplacental transfer of mRNA vaccine products and functional SARS-CoV-2 antibodies during pregnancy and early infancy.
DOI：
10.1038/s41379-022-01061-3
发表时间：
2022-09
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
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作者：
Santos A;Sauer M;Neil AJ;Solomon IH;Hornick JL;Roberts DJ;Quade BJ;Parra-Herran C
通讯作者：
Parra-Herran C