Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience.
Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience.
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DOI：
10.1038/s41379-021-00793-y
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Fowkes ME
中科院分区：
文献类型：
--
作者：
Bryce C;Grimes Z;Pujadas E;Ahuja S;Beasley MB;Albrecht R;Hernandez T;Stock A;Zhao Z;AlRasheed MR;Chen J;Li L;Wang D;Corben A;Haines GK 3rd;Westra WH;Umphlett M;Gordon RE;Reidy J;Petersen B;Salem F;Fiel MI;El Jamal SM;Tsankova NM;Houldsworth J;Mussa Z;Veremis B;Sordillo E;Gitman MR;Nowak M;Brody R;Harpaz N;Merad M;Gnjatic S;Liu WC;Schotsaert M;Miorin L;Aydillo Gomez TA;Ramos-Lopez I;Garcia-Sastre A;Donnelly R;Seigler P;Keys C;Cameron J;Moultrie I;Washington KL;Treatman J;Sebra R;Jhang J;Firpo A;Lednicky J;Paniz-Mondolfi A;Cordon-Cardo C;Fowkes ME
严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 及其相关临床综合征 COVID-19 在全球范围内造成极高的发病率和死亡率，并在 2020 年 3 月至 5 月期间对纽约市造成了不成比例的影响。在此，我们报告了纽约市西奈山医院进行的首批 100 例 COVID-19 阳性尸检。尸检发现六例存在大的肺栓塞。 90%以上的病例存在弥漫性肺泡损伤。我们还报告了包括大脑在内的多个器官系统中的微血栓以及噬血作用。我们还提供了样本中存在病毒的电子显微镜证据。我们的 COVID-19 队列的实验室结果显示炎症标志物升高、凝血值异常以及细胞因子 IL-6、IL-8 和 TNFα 升高。我们对 COVID-19 阳性患者的尸检系列表明，这种疾病通常被概念化为主要的呼吸道病毒性疾病，对体内具有广泛的影响，包括高凝状态、高炎症状态和内皮功能障碍。针对这些多系统途径可能会带来新的治疗途径以及针对 SARS-CoV-2 感染的联合疗法。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe and disproportionately affected New York City between March and May 2020. Here, we report on the first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City. Autopsies revealed large pulmonary emboli in six cases. Diffuse alveolar damage was present in over 90% of cases. We also report microthrombi in multiple organ systems including the brain, as well as hemophagocytosis. We additionally provide electron microscopic evidence of the presence of the virus in our samples. Laboratory results of our COVID-19 cohort disclose elevated inflammatory markers, abnormal coagulation values, and elevated cytokines IL-6, IL-8, and TNFα. Our autopsy series of COVID-19-positive patients reveals that this disease, often conceptualized as a primarily respiratory viral illness, has widespread effects in the body including hypercoagulability, a hyperinflammatory state, and endothelial dysfunction. Targeting of these multisystemic pathways could lead to new treatment avenues as well as combination therapies against SARS-CoV-2 infection.
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影响因子：
3.5
作者：
Boesmueller, Hans;Traxler, Selina;Fend, Falko
通讯作者：
Fend, Falko
影响因子：
120.7
作者：
Koton, Silvia;Schneider, Andrea L. C.;Coresh, Josef
通讯作者：
Coresh, Josef
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
DOI：
10.1038/nri3846
发表时间：
2015-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
2.1
作者：
Edler, Carolin;Schroeder, Ann Sophie;Sperhake, Jan-Peter
通讯作者：
Sperhake, Jan-Peter