Race, ethnicity and risk of second primary contralateral breast cancer in the United States.
Race, ethnicity and risk of second primary contralateral breast cancer in the United States.
复制标题
DOI：
10.1002/ijc.33501
复制
发表时间：
2021-06-01
影响因子：
6.4
通讯作者：
Bernstein, Jonine L.
中科院分区：
文献类型：
--
作者：
Watt, Gordon P.;John, Esther M.;Bandera, Elisa V.;Malone, Kathleen E.;Lynch, Charles F.;Palmer, Julie R.;Knight, Julia A.;Troester, Melissa A.;Bernstein, Jonine L.
乳腺癌幸存者发生第二原发性对侧乳腺癌（CBC）的风险很高，但很少有少数人群CBC风险的研究。我们研究了CBC的发病率和危险因素是否因美国的种族/民族而异。在2000年至2015年期间，在监测、流行病学和最终结果计划（SEER）18项登记研究中，首次诊断为浸润性I-IIB期乳腺癌的女性在首次乳腺癌诊断后≥1年，随访至2016年。我们使用原因特异性考克斯比例风险模型来检验人种/种族与CBC之间的关联，调整年龄、激素受体状态、放疗、化疗和首次诊断时的分期，并评估对侧预防性乳房切除术、社会经济状况和保险状况对该关联的影响。经过5.9年的中位随访，9，247名女性（2.0%）被诊断患有CBC。相对于非西班牙裔（NH）白色女性，CBC风险在NH黑人女性（风险比= 1.44，95%CI 1.35-1.54）和西班牙裔女性（1.11，95%CI 1.02-1.20）中增加，在年轻时诊断的女性中差异最大。对侧预防性乳房切除术、社会经济地位和健康保险的调整并不能解释这种关联。因此，非西班牙裔黑人和西班牙裔妇女CBC的风险增加，这不能用SEER中收集的临床或社会经济因素来解释。需要对不同的乳腺癌幸存者进行大型研究，并提供有关治疗提供和依从性的详细数据，以便为减少这种差异的干预措施提供信息。
Breast cancer survivors have a high risk of a second primary contralateral breast cancer (CBC), but there are few studies of CBC risk in minority populations. We examined whether the incidence and risk factors for CBC differed by race/ethnicity in the United States. Women with a first invasive stage I-IIB breast cancer diagnosis at ages 20–74 years between 2000 and 2015 in the Surveillance, Epidemiology, and End Results Program (SEER) 18 registries were followed through 2016 for a diagnosis of invasive CBC ≥1 year after the first breast cancer diagnosis. We used cause-specific Cox proportional hazards models to test the association between race/ethnicity and CBC, adjusting for age, hormone receptor status, radiation therapy, chemotherapy, and stage at first diagnosis, and evaluated the impact of contralateral prophylactic mastectomy, socioeconomic status, and insurance status on the association. After a median follow-up of 5.9 years, 9,247 women (2.0%) were diagnosed with CBC. Relative to non-Hispanic (NH) White women, CBC risk was increased in NH Black women (hazard ratio = 1.44, 95% CI 1.35–1.54) and Hispanic women (1.11, 95% CI 1.02–1.20), with the largest differences among women diagnosed at younger ages. Adjustment for contralateral prophylactic mastectomy, socioeconomic status, and health insurance did not explain the associations. Therefore, non-Hispanic Black and Hispanic women have an increased risk of CBC that is not explained by clinical or socioeconomic factors collected in SEER. Large studies of diverse breast cancer survivors with detailed data on treatment delivery and adherence are needed to inform interventions to reduce this disparity.
登录
查看更多内容
DOI：
10.1007/s10552-018-1043-y
发表时间：
2018-07
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Dean LT;Gehlert S;Neuhouser ML;Oh A;Zanetti K;Goodman M;Thompson B;Visvanathan K;Schmitz KH
通讯作者：
Schmitz KH
根据激素受体状态，小叶原位癌后第二次乳腺癌的风险
影响因子：
3.7
作者：
Mao K;Yang Y;Wu W;Liang S;Deng H;Liu J
通讯作者：
Liu J
影响因子：
10.3
作者：
Kramer，Iris;Schaapveld，Michael;Schmidt，Marjanka K.
通讯作者：
Schmidt，Marjanka K.
影响因子：
6.2
作者：
Haas, Jennifer S.;Earle, Craig C.;Williams, David R.
通讯作者：
Williams, David R.
影响因子：
3.2
作者：
Haque, Reina;Xu, Xiaoqing;Chlebowski, Rowan T.
通讯作者：
Chlebowski, Rowan T.