Innate immune activation and depressive and anxious symptoms across the peripartum: An exploratory study.
Innate immune activation and depressive and anxious symptoms across the peripartum: An exploratory study.
复制标题
DOI：
10.1016/j.psyneuen.2018.08.038
复制
发表时间：
2019-01
影响因子：
3.7
通讯作者：
Sperling R
中科院分区：
文献类型：
--
作者：
Osborne LM;Yenokyan G;Fei K;Kraus T;Moran T;Monk C;Sperling R
免疫功能和精神疾病之间存在复杂的关联，但围产期的研究主要集中在个别炎症标志物和抑郁症状上，仅在横断面上。我们试图研究抑郁和焦虑症状与围产期免疫激活之间的纵向关联。我们测量了51名妇女在怀孕和产后5个时间点的情绪（贝克抑郁量表，BDI-1A）和焦虑（状态-特质焦虑量表，STATE）以及23种细胞因子的水平。使用具有随机截距和斜率的线性混合效应模型，通过抑郁和焦虑症状分组评估受试者内细胞因子随时间的轨迹。我们还进行了探索性聚类分析的基础上，晚期妊娠细胞因子值。基于分类BDI评分，IL-6（p < 0.001），IL-15（p = 0.047），GCSF（p = 0.003）和CCL 3（p < .001）在不同时间有显著差异，IL-6在更抑郁的受试者中，IL-15（p = 0.003）和CCL 3（p < 0.001）在妊娠晚期访视时更高。基于分类STATE评分，对于焦虑程度较低的受试者，GM-CSF在整个妊娠期间显著降低（p =0.016），但对于焦虑程度较高的受试者，则没有显著降低;对于焦虑程度较高的受试者，在妊娠晚期访视时，CCL 3（p = 0.017）、CXCL 8（p = 0.011）和IL-6（p < 0.001）较高。在基于细胞因子水平的探索性聚类分析中，情绪或焦虑评分没有差异，但种族/民族和超重/肥胖状态存在显著差异。与促炎细胞因子值较低的女性相比，促炎细胞因子值较高的女性更可能是西班牙裔（69.2% vs. 21.4%，p = 0.015），但不太可能是非洲裔美国人（23.1% vs. 60.7%，p=0.015）或超重/肥胖（25% vs. 69.2%，p = 0.016）。我们在妊娠晚期发现了一种促炎爆发，表明先天免疫激活，在抑郁和焦虑症状水平较高的女性中，以及随着时间的推移促炎变化的差异。我们还发现，不同种族、民族和超重/肥胖状态的细胞因子水平存在显著差异。这些结果指出了未来的纵向工作，考虑种族/民族，时间和体重状况，并评估围产期情绪和焦虑症的背景下，在整个围产期的免疫功能变化的方式。
There are complex associations between immune function and mental illness, yet studies in the perinatal period focus primarily on individual inflammatory markers and depressive symptoms only, cross-sectionally. We sought to examine associations between both depressive and anxious symptoms and immune activation longitudinally across the peripartum. We measured mood (Beck Depression Inventory, BDI-1A) and anxiety (State-Trait Anxiety Inventory, STATE) and levels of 23 cytokines at 5 points in pregnancy and postpartum in 51 women. Within subject cytokine trajectories over time by depressive and anxious symptom grouping were assessed using linear mixed effects models with random intercept and slope. We also undertook an exploratory cluster analysis based on third trimester cytokine values. Based on categorical BDI scores, IL-6 (p < 0.001), IL-15 (p = 0.047), GCSF (p = 0.003), and CCL3 (p < .001) were significantly different across time, with IL-6 (p < 0.001), IL-15 (p = 0.003), and CCL3 (p < 0.001) higher at the third trimester visit in more depressed subjects. Based on categorical STATE scores, GM-CSF significantly decreased across pregnancy for the less anxious group (p =0.016), but not for the more anxious, and CCL3 (p = 0.017), CXCL8 (p = 0.011), and IL-6 (p < 0.001) were higher at the third trimester visit for more anxious subjects. In exploratory cluster analysis based on cytokine level, there were no differences in mood or anxiety scores, but significant differences by race/ethnicity and overweight/obesity status. Women with higher pro-inflammatory cytokine values are more likely to be Hispanics (69.2% vs. 21.4%, p = 0.015), but less likely to be African American (23.1% vs. 60.7%, p=0.015) or overweight/obese (25% vs. 69.2%, p = 0.016) compared to women with lower pro-inflammatory cytokine values. We identified a pro-inflammatory burst at the third trimester, indicative of innate immune activation, in women with higher levels of both depressive and anxious symptoms, as well as differences in pro-inflammatory changes across time. We also found significant differences in cytokine levels by race, ethnicity, and overweight/obesity status. These results point the way toward future longitudinal work that considers race/ethnicity, timing, and weight status, and evaluates perinatal mood and anxiety disorders in the context of changing immune functioning across the peripartum.
登录
查看更多内容
影响因子：
12.4
作者：
Ha H;Debnath B;Neamati N
通讯作者：
Neamati N
影响因子：
2.1
作者：
Baba T;Mukaida N
通讯作者：
Mukaida N
影响因子：
11.3
作者：
Aalto, Anna-Mari;Elovainio, Marko;Pirkola, Sami
通讯作者：
Pirkola, Sami
海南黎族和汉族创伤后应激障碍患者血清细胞因子和皮质醇水平的比较研究
影响因子：
6.1
作者：
Chen Tao;Guo Min;Jiang Xianglin
通讯作者：
Jiang Xianglin
影响因子：
3.7
作者：
Edvinsson, Asa;Brann, Emma;Sundstrom-Poromaa, Inger
通讯作者：
Sundstrom-Poromaa, Inger