What disorders of cortical development tell us about the cortex: one plus one does not always make two.
What disorders of cortical development tell us about the cortex: one plus one does not always make two.
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皮质发育的疾病告诉我们有关皮质的疾病：一个加一个并不总是两个。
DOI：
10.1016/j.gde.2011.01.006
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发表时间：
2011-06
影响因子：
4
通讯作者：
Walsh, Christopher A.
中科院分区：
文献类型：
--
作者：
Manzini, M. Chiara;Walsh, Christopher A.
人类大脑皮层独特的大小和复杂性是通过长期和精确调控的发育过程控制神经发生，神经元迁移和分化实现的。传统上，皮质发育障碍是根据这些发育步骤中最明显的缺陷来分类的。然而，我们对皮层发育所必需的基因的细胞生物学作用了解得越多，我们就越意识到这些功能映射到分子过程，但不是那么干净地映射到解剖过程。必需基因可能参与增殖和迁移以及分化，反映了在不同发育阶段的潜在分子机制的作用，并导致各种各样的皮质缺陷。
The unique size and complexity of the human cerebral cortex are achieved via a long and precisely regulated developmental process controlling neurogenesis, neuronal migration and differentiation. Traditionally, disorders of cortical development have been classified on the basis of the most obvious defects in one of these developmental steps. However, the more we learn about the cellular biological roles of genes that are essential for cortical development, the more we realize that these functions map onto molecular processes, but not so cleanly onto anatomical processes. Essential genes might be involved both in proliferation and migration as well as differentiation, reflecting roles for underlying molecular mechanisms in different phases of development and causing a stunning variety of cortical defects.
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