Antibacterials from the sea.
Antibacterials from the sea.
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DOI：
10.1002/chem.201001279
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发表时间：
2010-11-08
影响因子：
4.3
通讯作者：
Fenical, William
中科院分区：
文献类型：
--
作者：
Hughes, Chambers C.;Fenical, William
海洋在一个巨大的微生物汤中包含了大量的宏观生命。与陆地环境不同，水环境提供永久的接近性，并模糊了空间差异。海洋生物受到包括细菌在内的常驻病原微生物感染的持续威胁，因此，它们从一系列不同的生物前体中改造出具有抗菌活性的复杂有机化合物。海洋的稀释作用推动了强有力的分子的构建，这些分子在恶劣的盐条件下是稳定的。各类代谢物的成员-核糖体和非核糖体肽、生物碱、聚酮化合物和萜烯-已显示出抗菌活性。这些代谢物的复杂性和多样性表明了自然界生物合成过程的独创性和灵活性。与陆生植物相比，海洋抗菌天然产物受到的关注要少得多。因此，共同努力从海洋资源中发现新的抗菌药物，有可能大大有助于治疗日益增加的耐药性传染病。
The ocean contains a host of macroscopic life in a great microbial soup. Unlike the terrestrial environment, an aqueous environment provides perpetual propinquity and blurs spatial distinctions. Marine organisms are under a persistent threat of infection by resident pathogenic microbes including bacteria, and in response they have engineered complex organic compounds with antibacterial activity from a diverse set of biological precursors. The diluting effect of the ocean drives the construction of potent molecules that are stable to harsh salty conditions. Members of each class of metabolite—ribosomal and non-ribosomal peptides, alkaloids, polyketides, and terpenes—have been shown to exhibit antibacterial activity. The sophistication and diversity of these metabolites points to the ingenuity and flexibility of biosynthetic processes in Nature. Compared with their terrestrial counterparts, antibacterial marine natural products have received much less attention. Thus, a concerted effort to discover new antibacterials from marine sources has the potential to contribute significantly to the treatment of the ever increasing drug-resistant infectious diseases.
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影响因子：
16.6
作者：
Arndt, Hans-Dieter;Riedrich, Matthias
通讯作者：
Riedrich, Matthias
DOI：
10.1073/pnas.0900008106
发表时间：
2009-02-24
影响因子：
11.1
作者：
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通讯作者：
Fischbach, Michael A.
影响因子：
1.8
作者：
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通讯作者：
Jayatilake, GS
影响因子：
3.3
作者：
Baz, JP;Canedo, LM;Elipe, MVS
通讯作者：
Elipe, MVS
影响因子：
3.6
作者：
Barsby, Todd;Warabi, Kaoru;Andersen, Raymond J.
通讯作者：
Andersen, Raymond J.