Non-autophagic roles of autophagy-related proteins.

Non-autophagic roles of autophagy-related proteins.
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自噬相关蛋白的非自助质作用。

DOI:
10.1038/embor.2012.220
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发表时间:
2013-02
期刊:
影响因子:
7.7
通讯作者:
Malhotra, Vivek
Malhotra, Vivek
中科院分区:
生物学2区
文献类型:
--
作者:
Subramani, Suresh;Malhotra, Vivek

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自噬和自噬相关过程在人类健康和疾病中至关重要。这些过程主要被视为细胞降解途径,将大分子和功能失调或多余的细胞器回收为氨基酸,糖和脂质,特别是在饥饿期间。然而,泛蛋白样自噬蛋白和自噬机制的其他成分也参与细胞重编程。我们强调自噬蛋白的这些非自噬作用,目的是引起人们对这个不断增长但尚未探索的研究课题的关注。我们专注于非自噬功能的自噬蛋白在细胞存活和凋亡,细胞交通,蛋白质分泌,细胞信号,转录,翻译和膜重组的调制。
Autophagy and autophagy-related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the ubiquitin-like autophagy proteins and other components of the autophagic machinery additionally participate in cellular reprogramming. We highlight these non-autophagic roles of autophagy proteins with the aim of drawing attention to this growing, but unexplored, research topic. We focus on the non-autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization.
DOI: 10.1083/jcb.201106098
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影响因子: --
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