Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China.
Clinicopathological characteristics and prognostic analysis of Lauren classification in gastric adenocarcinoma in China.
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DOI：
10.1186/1479-5876-11-58
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发表时间：
2013-03-06
影响因子：
7.4
通讯作者：
Xu RH
中科院分区：
文献类型：
--
作者：
Qiu MZ;Cai MY;Zhang DS;Wang ZQ;Wang DS;Li YH;Xu RH
According to the Lauren classification, gastric adenocarcinomas are divided into diffuse and intestinal types. The causative attribution explaining the dismal prognosis of diffuse-type remains unknown. We examined the archive of 1000 patients with gastric adenocarcinomas who received radical gastrectomy in our center and assessed the effect of the Lauren classification on survival in a multivariate approach. Moreover we compared the variation of clinical features between the diffuse-type and intestinal-type and explored the contributing factors for the prognostic difference. There were 805 resectable patients for the final analysis. Diffuse-type comprised of 48.7% in the gastric carcinoma in our group and showed poorer prognosis than intestinal-type (P=0.013). Multivariate analysis revealed that independent prognostic factors for gastric carcinoma patients were T stage (P<0.001), N stage (P<0.001) tumor size (P<0.001) and Lauren classification (P=0.003). For the clinical features, diffuse-type was significantly associated with younger age (p<0.001), female preponderance (p <0.001), distal location (P<0.001), advanced pT (p < 0.001), advanced pN (p < 0.001) and advanced TNM stage (p = 0.027). Diffuse type adenocarcinoma carries a worse prognosis that may be partially explained by the tendency of this subtype to present at more advanced T and N stage. However, Lauren classification has prognostic significance that is independent of T and N stage as well as other prognostic variables based on the multivariate cox analysis.
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DOI：
10.1111/apm.1965.64.1.31
发表时间：
1965-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
LAUREN, P
通讯作者：
LAUREN, P
影响因子：
3.4
作者：
Zheng, Huachuan;Takahashi, Hiroyuki;Takano, Yasuo
通讯作者：
Takano, Yasuo
DOI：
10.1111/j.1440-1746.2007.04991.x
发表时间：
2007-09-01
影响因子：
4.1
作者：
Miyahara, Ryoji;Niwa, Yasumasa;Goto, Hidemi
通讯作者：
Goto, Hidemi
影响因子：
45.3
作者：
Van Cutsem, Eric;Moiseyenko, Vladimir M.;Ajani, Jaffer A.
通讯作者：
Ajani, Jaffer A.
影响因子：
--
作者：
Qiu, Miao-zhen;Wang, Zhi-qiang;Xu, Rui-hua
通讯作者：
Xu, Rui-hua