Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm.
Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm.
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DOI：
10.1080/15592294.2023.2280738
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发表时间：
2023-12
期刊：
影响因子：
3.7
通讯作者：
Everson, Todd M.
中科院分区：
文献类型：
--
作者：
Paniagua, Uriel;Lester, Barry M.;Marsit, Carmen J.;Camerota, Marie;Carter, Brian S.;Check, Jennifer F.;Helderman, Jennifer;Hofheimer, Julie A.;Mcgowan, Elisabeth C.;Neal, Charles R.;Pastyrnak, Steven L.;Smith, Lynne M.;DellaGrotta, Sheri A.;Dansereau, Lynne M.;O'Shea, T. Michael;Everson, Todd M.
表观遗传性衰老加速是慢性衰老疾病的一个风险因素，可能反映了生物衰老的某些方面。然而，很少有研究探讨了早产儿在新生儿早期的表观遗传衰老，他们面临着更高的发育问题风险。我们研究了极早产儿（妊娠<30周）中新生儿年龄加速、新生儿发病率和神经行为领域之间的关系，以表征具有早期发病率或不同神经行为特征的婴儿是否加速或减缓了表观遗传衰老。本研究使用来自极早产儿（诺维）研究的新生儿神经行为和结局的数据，仅限于具有评估变量数据的婴儿（n = 519）。我们使用广义估计方程来检验与严重新生儿内科疾病和神经行为特征相关的年龄加速差异。我们发现，患有新生儿疾病的婴儿，特别是支气管肺发育不良（BPD）的婴儿，具有加速的表观遗传年龄-以及一些证据表明，高张性和不对称反射的婴儿分别增加和减少了年龄加速。调整胎龄减弱了一些关联，表明观察到的关系可能是由妊娠持续时间驱动的。我们最有力的发现表明，极早产儿与新生儿发病率（BPD特别是）表现出年龄加速，但大多数新生儿神经行为特征和发病率与早期生活年龄加速无关。出生时较低的胎龄可能是推动这些关联的上游因素。
Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neonatal period in preterm infants, who are at heightened risk of developmental problems. We examined relationships between neonatal age acceleration, neonatal morbidities, and neurobehavioral domains among very preterm (<30 weeks gestation) infants to characterize whether infants with early morbidities or different neurobehavioral characteristics had accelerated or decelerated epigenetic ageing. This study uses data from the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) study, restricted to infants with data on variables assessed (n = 519). We used generalized estimating equations to test for differences in age acceleration associated with severe neonatal medical morbidities and neurobehavioral characteristics. We found that infants with neonatal morbidities, in particular, bronchopulmonary dysplasia (BPD), had accelerated epigenetic age – and some evidence that infants with hypertonicity and asymmetric reflexes had increased and decreased age acceleration, respectively. Adjustment for gestational age attenuated some associations, suggesting that the relationships observed may be driven by the duration of gestation. Our most robust finding shows that very preterm infants with neonatal morbidities (BPD in particular) exhibit age acceleration, but most neonatal neurobehavioral characteristics and morbidities are not associated with early life age acceleration. Lower gestational age at birth may be an upstream factor driving these associations.
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影响因子：
5.7
作者：
Haftorn KL;Lee Y;Denault WRP;Page CM;Nustad HE;Lyle R;Gjessing HK;Malmberg A;Magnus MC;Næss Ø;Czamara D;Räikkönen K;Lahti J;Magnus P;Håberg SE;Jugessur A;Bohlin J
通讯作者：
Bohlin J
DOI：
10.18632/aging.203637
发表时间：
2021-10-16
期刊：
Aging
影响因子：
--
作者：
Graw S;Camerota M;Carter BS;Helderman J;Hofheimer JA;McGowan EC;Neal CR;Pastyrnak SL;Smith LM;DellaGrotta SA;Dansereau LM;Padbury JF;O'Shea M;Lester BM;Marsit CJ;Everson TM
通讯作者：
Everson TM
影响因子：
5.7
作者：
Dieckmann L;Lahti-Pulkkinen M;Kvist T;Lahti J;DeWitt PE;Cruceanu C;Laivuori H;Sammallahti S;Villa PM;Suomalainen-König S;Eriksson JG;Kajantie E;Raikkönen K;Binder EB;Czamara D
通讯作者：
Czamara D
稳定性选择可增强特征选择，并仅使用五个DNA甲基化位点才能准确预测胎龄。
影响因子：
5.7
作者：
Haftorn, Kristine L. L.;Romanowska, Julia;Lee, Yunsung;Page, Christian M. M.;Magnus, Per M. M.;Haberg, Siri E. E.;Bohlin, Jon;Jugessur, Astanand;Denault, William R. P.
通讯作者：
Denault, William R. P.
DOI：
10.1136/archdischild-2021-323405
发表时间：
2022-08-23
影响因子：
4.4
作者：
Martin, Monika;Smith, Lynne;Lester, Barry M.
通讯作者：
Lester, Barry M.