NO, ROS, RAS, and PVAT: More Than a Soup of Letters.

NO, ROS, RAS, and PVAT: More Than a Soup of Letters.
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DOI:
10.3389/fphys.2021.640021
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发表时间:
2021
影响因子:
4
通讯作者:
Assreuy J
Assreuy J
中科院分区:
医学2区
文献类型:
--
作者:
Barp CG;Bonaventura D;Assreuy J

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血管周围脂肪组织(PVAT)最近已作为干预的假定目标进入心血管疾病领域。尽管具有相关性,但要充分了解 PVAT 在生理学和病理学中的作用还有很长的路要走。 PVAT 的抗收缩作用是有益的,而其促收缩作用是有害的这一普遍观点受到一些报告的质疑。一些PVAT重要产物或系统,如一氧化氮(NO)、活性氧(ROS)和RAS,其作用可能因环境、疾病、生产地点等而异,这增加了人们对PVAT抗收缩和促收缩作用的介质如何发挥作用及其最终结果的疑问。这篇简短的综述将讨论有关 NO、ROS 和 RAS 在 PVAT 的有益和有害作用中的一些观点。
Perivascular adipose tissue (PVAT) has recently entered in the realm of cardiovascular diseases as a putative target for intervention. Notwithstanding its relevance, there is still a long way before the role of PVAT in physiology and pathology is fully understood. The general idea that PVAT anti-contractile effect is beneficial and its pro-contractile effect is harmful is being questioned by several reports. The role of some PVAT important products or systems such as nitric oxide (NO), reactive oxygen species (ROS), and RAS may vary depending on the context, disease, place of production, etc., which adds doubts on how mediators of PVAT anti- and pro-contractile effects are called to action and their final result. This short review will address some points regarding NO, ROS, and RAS in the beneficial and harmful roles of PVAT.
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