Novel functional magnetic resonance imaging biomarkers for assessing response to therapy in hepatocellular carcinoma

Novel functional magnetic resonance imaging biomarkers for assessing response to therapy in hepatocellular carcinoma
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用于评估肝细胞癌治疗反应的新型功能性磁共振成像生物标志物

DOI:
10.1007/s12094-013-1147-5
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发表时间:
2013
期刊:
Clin Transl Oncol
影响因子:
--
通讯作者:
W.-J. Peng
W.-J. Peng
中科院分区:
其他
文献类型:
--
作者:
W.-T. Li;X.-D. Ye;H.-Y. Zhu;W.-J. Peng

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基于肿瘤负荷测量的基于大小的已建立和适应的图像生物标志物继续应用于肝细胞癌(HCC),因为大小测量可以很容易地用于临床实践。然而,在新的靶向治疗和肝脏定向治疗的背景下,简单的肿瘤解剖变化可能信息较少,通常出现在生物学变化之后。功能磁共振成像(MRI)有潜力成为HCC治疗反应评估的一种有前景的技术。在这篇综述中,我们讨论了各种功能性MRI生物标志物,它们在HCC治疗后反应的评估中发挥着越来越重要的作用。
The established and adapted image biomarkers based on size for tumor burden measurement continue to be applied to hepatocellular carcinoma (HCC) as size measurement can easily be used in clinical practice. However, in the setting of novel targeted therapies and liver directed treatments, simple tumor anatomical changes can be less informative and usually appear later than biological changes. Functional magnetic resonance imaging (MRI) has a potential to be a promising technique for assessment of HCC response to therapy. In this review, we discuss various functional MRI biomarkers that play an increasingly important role in evaluation of HCC response after treatment.
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