Anopheles mortality is both age- and Plasmodium-density dependent: implications for malaria transmission.
Anopheles mortality is both age- and Plasmodium-density dependent: implications for malaria transmission.
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Anopheles的死亡率既取决于年龄和疟原虫密度：对疟疾传播的影响。
DOI：
10.1186/1475-2875-8-228
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发表时间：
2009-10-12
期刊：
影响因子：
3
通讯作者：
Basáñez MG
中科院分区：
文献类型：
--
作者：
Dawes EJ;Churcher TS;Zhuang S;Sinden RE;Basáñez MG
每日死亡率是媒介传播病原体能力的重要决定因素。疟疾传播模型中最初的简化假设假设媒介死亡率与年龄、感染状况和寄生虫载量无关。以前的研究表明，关于疟原虫引起的媒介死亡的重要性，存在相互矛盾的证据，但到目前为止，很少有研究考虑感染密度对蚊子生存的影响。进行了一系列三个实验，每个实验由四个笼子组成，每个笼子里有400-1000只斯氏按蚊，以每微升血液中感染了不同伯氏疟原虫运动密度的血液为食。每天两次记录每组蚊子的死亡数量，并每隔一天解剖每组活蚊子样本，以确定中肠和唾液腺中的寄生虫密度。生存分析表明，蚊子的死亡率与年龄和感染强度有关。蚊子经历了最初的高死亡率，部分与摄食有关，随着蚊子年龄和寄生虫摄入量的增加，死亡率下降到最低水平。结果表明，蚊子的预期寿命取决于虫龄和疟原虫感染密度。这些结果有助于更详细地了解影响蚊子造孢子的过程，表明寄生虫密度可能对疟疾传播动态产生的影响，并对传播阻断策略的设计、开发和评估产生影响。
Daily mortality is an important determinant of a vector's ability to transmit pathogens. Original simplifying assumptions in malaria transmission models presume vector mortality is independent of age, infection status and parasite load. Previous studies illustrate conflicting evidence as to the importance of Plasmodium-induced vector mortality, but very few studies to date have considered the effect of infection density on mosquito survival. A series of three experiments were conducted, each consisting of four cages of 400-1,000 Anopheles stephensi mosquitoes fed on blood infected with different Plasmodium berghei ookinete densities per microlitre of blood. Twice daily the numbers of dead mosquitoes in each group were recorded, and on alternate days a sample of live mosquitoes from each group were dissected to determine parasite density in both midgut and salivary glands. Survival analyses indicate that mosquito mortality is both age- and infection intensity-dependent. Mosquitoes experienced an initially high, partly feeding-associated, mortality rate, which declined to a minimum before increasing with mosquito age and parasite intake. As a result, the life expectancy of a mosquito is shown to be dependent on both insect age and the density of Plasmodium infection. These results contribute to understanding in greater detail the processes that influence sporogony in the mosquito, indicate the impact that parasite density could have on malaria transmission dynamics, and have implications for the design, development, and evaluation of transmission-blocking strategies.
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DOI：
10.1007/bf00929172
发表时间：
1979-01-01
期刊：
ZEITSCHRIFT FUR PARASITENKUNDE-PARASITOLOGY RESEARCH
影响因子：
--
作者：
GAD, AM;MAIER, WA;PIEKARSKI, G
通讯作者：
PIEKARSKI, G
影响因子：
5.7
作者：
CLEMENTS, AN;PATERSON, GD
通讯作者：
PATERSON, GD
影响因子：
5.8
作者：
Ahmed, AM;Hurd, H
通讯作者：
Hurd, H
影响因子：
9.6
作者：
Ferguson, HM;Read, AF
通讯作者：
Read, AF
影响因子：
1.5
作者：
Franke-Fayard, B;Trueman, H;Janse, CJ
通讯作者：
Janse, CJ