Development and initial validation of quality-of-life questionnaires for intermittent exotropia.
Development and initial validation of quality-of-life questionnaires for intermittent exotropia.
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DOI：
10.1016/j.ophtha.2009.06.038
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发表时间：
2010-01
期刊：
影响因子：
13.7
通讯作者：
Holmes JM
中科院分区：
文献类型：
--
作者：
Hatt SR;Leske DA;Yamada T;Bradley EA;Cole SR;Holmes JM
我们报告间歇性外斜视（IXT）患者衍生的健康相关生活质量（HRQOL）问卷的开发和初步验证。横断面研究在一个发展阶段，27名儿童（年龄2-17岁）与IXT和他们的父母之一。在初始验证阶段，33名IXT儿童和49名对照儿童（年龄5-17岁）沿着每个儿童的一名父母。对照组无斜视、弱视。个体患者访谈生成了35个项目的儿童和代理（父母评估儿童的HRQOL）问卷和46个项目的父母问卷。为了减少到可行的项目数，对5-17岁IXT儿童（n=15）和2-17岁IXT儿童的父母（n=27）进行问卷调查。使用标准的项目减少方法分析响应。三个最终衍生的IXT问卷（IXTQ）：儿童，代理人和父母（分别为12，12和17个项目）进行了管理，以儿童IXT和对照儿童，父母的IXT和对照儿童。Likert类型量表范围从“从不”（评分100，最佳HRQOL）到“几乎总是”（评分0，最差HRQOL）用于回答。使用Wilcoxon检验比较IXT组和对照组的中位评分。与对照组相比，IXT组的中位Child评分显著较低（HRQOL较差）：85（四分位数73-92）vs 92（79-96）; P=0.04。IXT儿童的代理IXTQ评分中位数显著低于对照组：83（75-94）vs 98（92-100）; P<0.0001。与对照组相比，IXT组的父母IXTQ评分中位数也显着较低：68（四分位数56-79）与93（87-99）; P<0.0001。我们已经开发并验证了一个新的3部分患者衍生的HRQOL问卷与IXT儿童和他们的父母，包括儿童，代理和父母问卷。这些问卷检测降低HRQOL与IXT儿童报告的儿童自己和他们的父母（代理报告）。儿童期IXT似乎也会影响父母的HRQOL。IXTQ HRQOL问卷在IXT的临床评估和临床试验中可能是有用的。
We report the development and initial validation of patient–derived, health related quality of life (HRQOL) questionnaires for intermittent exotropia (IXT). Cross-sectional study In a development phase, 27 children (aged 2–17 years) with IXT and one of their parents. In an initial validation phase, 33 children with IXT and 49 control children (aged 5–17 years) along with one parent for each child. Children in the control group had no strabismus or amblyopia. Individual patient interviews generated 35 items for Child and Proxy (parental assessment of child’s HRQOL) questionnaires and 46 items for a Parent questionnaire. To reduce to a feasible number of items, questionnaires were administered to 5–17 year old children with IXT (n=15) and parents of 2–17 year old children with IXT (n=27). Responses were analyzed using standard item reduction methodology. Three final derived IXT questionnaires (IXTQ): Child, Proxy, and Parent (12, 12, and 17 items respectively) were administered to children with IXT and control children, and to parents of IXT and control children. Likert-type scales ranging from ‘never’ (score 100, best HRQOL) to ‘almost always’ (score 0, worst HRQOL) were used for responses. Median scores for IXT and control groups, compared using Wilcoxon tests. Median Child scores were significantly lower (worse HRQOL) in the IXT group compared with the control group: 85 (quartiles 73–92) versus 92 (79–96); P=0.04. Median Proxy IXTQ scores were significantly lower for IXT children than controls: 83 (75–94) versus 98 (92–100); P<0.0001. Median Parent IXTQ scores were also significantly lower in the IXT group compared with the control group: 68 (quartiles 56–79) versus 93 (87–99); P<0.0001. We have developed and validated a new 3-part patient-derived HRQOL questionnaire for children with IXT and their parents, comprising Child, Proxy and Parent questionnaires. These questionnaires detect reduced HRQOL in children with IXT as reported by the child themselves and as perceived by their parents (proxy report). Childhood IXT also appears to affect the HRQOL of the parents. The IXTQ HRQOL questionnaires may prove useful in the clinical assessment of IXT and for clinical trials.
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3
作者：
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影响因子：
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作者：
Hatt, Sarah R.;Mohney, Brian G.;Holmes, Jonathan M.
通讯作者：
Holmes, Jonathan M.