NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues.
NF-KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues.
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DOI：
10.1186/1756-9966-27-53
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发表时间：
2008-10-19
期刊：
影响因子：
--
通讯作者：
Barutca S
中科院分区：
文献类型：
--
作者：
Meteoglu I;Erdogdu IH;Meydan N;Erkus M;Barutca S
透明细胞肾细胞癌（ccRCC）是成人肾脏最常见的肿瘤。已知许多因素参与了这种肿瘤的发生和发展。核因子κB （NF-κB）是一个基因家族，包括5个成员参与炎症和细胞凋亡等事件。本研究探讨NF-κB （p50亚基）在ccRCC中的作用及其与血管生成和细胞凋亡的关系。对40例ccRCC患者进行了福尔马林固定和石蜡包埋组织块的研究。免疫组织化学检测NF-κB （p50）、VEGF、EGFR、bc1-2、p53的表达。评价NF-κB与上述指标及临床病理表现的关系。40例ccRCC患者中检测到NF-κB表达35例（85%），VEGF 37例（92.5%），EGFR 38例（95%），bc1-2 33例（82.5%），p53 13例（32.5%）。统计分析显示，NF-κB表达与VEGF （p = 0.001）、EGFR （p = 0.004）、bc1-2 （p = 0.010）、p53 （p = 0.037）有显著相关性。NF-κB与肿瘤分级、分期、年龄、性别等参数无明显相关性。本研究结果表明，在ccRCC病例中，NF-κB与VEGF、EGFR、bc1-2和p53等血管生成和凋亡标志物相关。此外，这些结果不仅提示了NF-κB与ccRCC中VEGF、EGFR、bc1-2、p53的密切关系，还提示NF-κB是治疗化疗耐药ccRCC的潜在治疗靶点。
Clear cell renal cell carcinoma (ccRCC) is the most frequently encountered tumor in the adult kidney. Many factors are known to take part in the development and progression of this tumor. Nuclear factor kappa B (NF-κB) is a family of the genes that includes five members acting in events such as inflammation and apoptosis. In this study, the role of NF-κB (p50 subunit) in ccRCC and its relation to angiogenesis and apoptosis were investigated. Formalin-fixed and paraffin embedded tissue blocks from 40 patients with ccRCC were studied. Expressions of NF-κB (p50), VEGF, EGFR, bc1-2 and p53 were detected immunohistochemically. The relationship of NF-κB with these markers and clinicopathological findings were evaluated. The expression of NF-κB was detected in 35 (85%), VEGF in 37 (92.5%), EGFR in 38 (95%), bc1-2 in 33 (82.5%) and p53 in 13 (32.5%) of 40 ccRCC patients. Statistical analyses revealed a significant relation between NF-κB expression and VEGF (p = 0.001), EGFR (p = 0.004), bc1-2 (p = 0.010) and p53 (p = 0.037). There was no significant correlation between NF-κB and such parameters as tumor grade, stage, age and sex. The results of this study indicated that in ccRCC cases NF-κB was associated with markers of angiogenesis and apoptosis such as VEGF, EGFR, bc1-2 and p53. In addition, the results did not only suggest a close relationship between NF-κB and VEGF, EGFR, bc1-2 and p53 in ccRCC, but also indicate that NF-κB was a potential therapeutic target in the treatment of ccRCC resistant to chemotherapy.
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影响因子：
3.8
作者：
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