NF-kappa B genes have a major role in inflammatory breast cancer.
NF-kappa B genes have a major role in inflammatory breast cancer.
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NF-KAPPA B基因在炎症性乳腺癌中具有重要作用。
DOI：
10.1186/1471-2407-8-41
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发表时间：
2008-02-04
期刊：
影响因子：
3.8
通讯作者：
Bieche I
中科院分区：
文献类型：
--
作者：
Lerebours F;Vacher S;Andrieu C;Espie M;Marty M;Lidereau R;Bieche I
IBC（炎症性乳腺癌）是一种罕见的乳腺癌，具有特殊的表型。需要新的分子靶点来改善这种快速致命疾病的治疗。鉴于NF-κ B相关基因在细胞增殖、侵袭、血管生成和炎症中的作用，我们推测它们可能在IBC中失调。我们采用实时定量RT-PCR方法检测了35例IBC中60个NF-κ B相关基因的mRNA表达水平，并与22例IIB和III期非炎性乳腺癌进行比较。24例远处转移的乳腺癌作为“预后不良”的乳腺肿瘤对照。在60个NF-κ B相关基因中，有35个（58%）在IBC中表达显著高于非IBC。表达上调的基因为NF-κB基因（NFKB 1、RELA、IKBKG、NFKBIB、NFKB 2、REL、CHUK），凋亡基因（MCL 1 L、TNFAIP 3/A20、GADD 45 B、FASLG、MCL 1 S、IER 3L、TNFRSF 10 B/TRAILR 2），免疫应答基因（CD 40、CD 48、TNFSF 11/RANKL、TNFSF 11 A/RANK、CCL 2/MCP-1、CD 40 LG、IL 15、GBP 1）、增殖基因（CCND 2、CCND 3、CSF 1 R、CSF 1、SOD 2）、肿瘤促进基因（CXCL 12、SELE、TNC、VCAM 1、ICAM 1、PLAU/UPA）或血管生成基因（PTGS 2/COX 2、CXCL 1/GRO 1）。这35个基因中只有两个（PTGS 2/COX 2和CXCL 1/GRO 1）在乳腺癌转移中也上调。我们确定了一个与患者结局相匹配的五基因分子标记，包括IL 8和VEGF以及我们先前在同一系列IBC中确定为预后标志物的三个NF-κ B无关基因。NF-κB通路似乎在IBC中起主要作用，可能导致这种形式的乳腺癌的不寻常表型和侵袭性。NF-κ B相关基因的表达上调可能成为IBC治疗的新靶点。
IBC (Inflammatory Breast cancer) is a rare form of breast cancer with a particular phenotype. New molecular targets are needed to improve the treatment of this rapidly fatal disease. Given the role of NF-κB-related genes in cell proliferation, invasiveness, angiogenesis and inflammation, we postulated that they might be deregulated in IBC. We measured the mRNA expression levels of 60 NF-κB-related genes by using real-time quantitative RT-PCR in a well-defined series of 35 IBCs, by comparison with 22 stage IIB and III non inflammatory breast cancers. Twenty-four distant metastases of breast cancer served as "poor prognosis" breast tumor controls. Thirty-five (58%) of the 60 NF-κB-related genes were significantly upregulated in IBC compared with non IBC. The upregulated genes were NF-κB genes (NFKB1, RELA, IKBKG, NFKBIB, NFKB2, REL, CHUK), apoptosis genes (MCL1L, TNFAIP3/A20, GADD45B, FASLG, MCL1S, IER3L, TNFRSF10B/TRAILR2), immune response genes (CD40, CD48, TNFSF11/RANKL, TNFRSF11A/RANK, CCL2/MCP-1, CD40LG, IL15, GBP1), proliferation genes (CCND2, CCND3, CSF1R, CSF1, SOD2), tumor-promoting genes (CXCL12, SELE, TNC, VCAM1, ICAM1, PLAU/UPA) or angiogenesis genes (PTGS2/COX2, CXCL1/GRO1). Only two of these 35 genes (PTGS2/COX2 and CXCL1/GRO1)were also upregulated in breast cancer metastases. We identified a five-gene molecular signature that matched patient outcomes, consisting of IL8 and VEGF plus three NF-κB-unrelated genes that we had previously identified as prognostic markers in the same series of IBC. The NF-κB pathway appears to play a major role in IBC, possibly contributing to the unusual phenotype and aggressiveness of this form of breast cancer. Some upregulated NF-κB-related genes might serve as novel therapeutic targets in IBC.
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有关炎症性乳腺癌的最新信息。
DOI：
10.1186/bcr997
发表时间：
2005
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Lerebours F;Bieche I;Lidereau R
通讯作者：
Lidereau R
影响因子：
6.4
作者：
GUERIN, M;GABILLOT, M;RIOU, G
通讯作者：
RIOU, G
影响因子：
11.2
作者：
Bertucci, F;Finetti, P;Viens, P
通讯作者：
Viens, P
DOI：
10.1073/pnas.0403621101
发表时间：
2004-07-06
影响因子：
11.1
作者：
Biswas, DK;Shi, Q;Iglehart, JD
通讯作者：
Iglehart, JD
影响因子：
10.3
作者：
Hance, KW;Anderson, WF;Levine, PH
通讯作者：
Levine, PH