Detection of elevated serum beta-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1.
Detection of elevated serum beta-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1.
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暴露于 1 型人类免疫缺陷病毒的血清阴性中国个体中血清 β-趋化因子水平升高的检测。
DOI：
10.1086/321871
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Ching Li
中科院分区：
文献类型：
--
作者：
B. Shieh;Yao;Nai Ying Ko;Y. Liau;Yung Ching Liu;Hsi Hsun Lin;Pei Pei Chen;Ching Li
中国人不存在抑制人类免疫缺陷病毒（HIV）1型传播的CCR 5编码区突变，如CCR 5Delta 32和CCR 5 m303。然而，在台湾的9名中国受试者中，有多次性暴露于HIV的历史仍然未被感染，这表明确实存在某些抗HIV因素。因此，设计实验来研究保护该队列免受HIV感染的免疫机制。从这9名受试者和7名未暴露于HIV的健康人获得外周血样品，用于定量血清样品或外周血淋巴细胞分泌的β-趋化因子和白细胞介素16（IL-16）的水平。与对照组相比，在9名HIV未感染受试者中检测到几乎所有3种β趋化因子、活化调节因子、正常T细胞表达和分泌因子、巨噬细胞炎性蛋白（MIP）-1 α和MIP-1 β的血清水平显著更高（分别为P<0.05、P<0.05和P= 0.05），但未检测到IL-16。结果表明，在目前已鉴定的宿主基因和细胞因子中，β-趋化因子是保护中国人免受HIV感染的主要HIV抑制因子。
The mutations in the CCR5 coding region, such as CCR5Delta32 and CCR5m303, that suppress the transmission of human immunodeficiency virus (HIV) type 1 do not exist in Chinese people. However, 9 Chinese subjects in Taiwan with histories of multiple sexual exposures to HIV remained uninfected, suggesting that certain anti-HIV factors do indeed exist. Experiments were therefore designed to investigate the immune mechanism that protects this cohort against HIV infection. Peripheral blood samples from these 9 subjects and 7 healthy people who had not been exposed to HIV were obtained for the quantitation of the levels for beta-chemokines and interleukin 16 (IL-16) in serum samples or secreted by peripheral blood lymphocytes. Significantly higher serum levels for nearly all 3 beta-chemokines, regulation on activation, normal T cell-expressed and secreted, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta (P<.05, P<.05, and P=.05, respectively), but not IL-16, were detected in the 9 HIV-uninfected subjects as compared with control subjects. The result suggests that among the host genes and cellular factors thus far identified, beta-chemokines are the major HIV-suppressive factors that protect Chinese people from infection with HIV.
CCR5del32 在围产期 HIV-1 感染中的作用。
DOI：
10.1097/00042560-199712010-00003
发表时间：
1997
期刊：
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
影响因子：
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作者：
Rousseau,CM;Just,JJ;Abrams,EJ;Casabona,J;Stein,Z;King,MC
通讯作者：
King,MC