Age-associated cerebral atrophy in mouse lemur primates.
Age-associated cerebral atrophy in mouse lemur primates.
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DOI：
10.1016/j.neurobiolaging.2009.05.018
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发表时间：
2011-05
影响因子：
4.2
通讯作者：
Dhenain, Marc
中科院分区：
文献类型：
--
作者：
Kraska, Audrey;Dorieux, Olene;Picq, Jean-Luc;Petit, Fanny;Bourrin, Emmanuel;Chenu, Evelyne;Volk, Andreas;Perret, Martine;Hantraye, Philippe;Mestre-Frances, Nadine;Aujard, Fabienne;Dhenain, Marc
我们通过4.7特斯拉T2加权磁共振成像评估了鼠狐猴灵长类动物的局部脑萎缩。对30只年龄为1.9 - 11.3岁的动物进行成像。参与研究的23只年龄超过3岁的动物中有61%显示出萎缩过程。横断面分析表明，萎缩遵循一个渐进的路径，开始在额叶区域，然后涉及颞和/或顶叶部分的大脑，最后枕区。根据萎缩的不同阶段选择的5只动物的组织学评价表明，细胞外淀粉样蛋白沉积和tau病理学本身不能解释这种萎缩，细胞内淀粉样蛋白沉积与这种病理学更密切相关。这项研究表明，大多数与年龄有关的萎缩发生在鼠狐猴是由一个临床，不断发展，病理过程。通过MRI非侵入性地跟踪这种病理的能力将允许进一步表征它并评估其与涉及人类疾病（如阿尔茨海默病）的神经病理学病变的关系。
We assessed the regional brain atrophy in mouse lemur primates from 4.7Tesla T2-weighted magnetic resonance images. Thirty animals aged from 1.9 to 11.3 years were imaged. Sixty one percent of the 23 animals older than 3 years involved in the study displayed an atrophy process. Cross sectional analysis suggests that the atrophy follows a gradual pathway, starting in the frontal region then involving the temporal and/or the parietal part of the brain and finally the occipital region. Histological evaluation of five animals selected according to various stages of atrophy suggested that extracellular amyloid deposits and tau pathology can not explain by themselves this atrophy and that intracellular amyloid deposition is more closely linked to this pathology. This study suggests that most of the age-related atrophy occurring in mouse lemurs is caused by one clinical, evolving, pathological process. The ability to follow this pathology non invasively by MRI will allow to further characterize it and evaluate its relationship with neuropathological lesions that are involved in human diseases such as Alzheimer.
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影响因子：
1.6
作者：
Beltran, William A.;Vanore, Maria;Chahory, Sabine
通讯作者：
Chahory, Sabine
影响因子：
6
作者：
Casas, C;Sergeant, N;Pradier, L
通讯作者：
Pradier, L
影响因子：
12.7
作者：
Christensen, Ditte Zerlang;Kraus, Sophie Luise;Bayer, Thomas A.
通讯作者：
Bayer, Thomas A.
DOI：
10.1007/bfb0056313
发表时间：
1998-01-01
期刊：
MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI'98
影响因子：
--
作者：
Mangin, JF;Coulon, O;Frouin, V
通讯作者：
Frouin, V
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y