Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children.
Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children.
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DOI：
10.3390/nu10091128
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发表时间：
2018-08-21
期刊：
影响因子：
5.9
通讯作者：
Oriá RB
中科院分区：
文献类型：
--
作者：
de Medeiros PHQS;Pinto DV;de Almeida JZ;Rêgo JMC;Rodrigues FAP;Lima AÂM;Bolick DT;Guerrant RL;Oriá RB
微量营养素维生素A是指一组对人体健康具有多效性作用的化合物。这些分子可以调节生物学功能，包括发育，视力和肠道屏障的调节。关于发展中国家儿童缺乏维生素A和补充维生素A的后果，已经探讨了好几年。这些儿童生活在肠道病原体高度污染的环境中，这反过来又会影响维生素A的状况。维生素A已被描述为调节基因表达，分化和各种免疫细胞的功能;然而，其潜在机制尚未完全阐明。本文综述了维生素A对肠道免疫和屏障功能影响的最新研究进展，有助于进一步了解儿童营养不良和肠道感染的负担。具体而言，通过涵盖临床和体内/体外数据，我们描述了维生素A相关的肠道免疫耐受/稳态，肠道屏障的完整性，并在环境肠道功能障碍的背景下对肠道病原体的反应的影响。还强调了需要进一步研究的文献中的一些差距。
The micronutrient vitamin A refers to a group of compounds with pleiotropic effects on human health. These molecules can modulate biological functions, including development, vision, and regulation of the intestinal barrier. The consequences of vitamin A deficiency and supplementation in children from developing countries have been explored for several years. These children live in an environment that is highly contaminated by enteropathogens, which can, in turn, influence vitamin A status. Vitamin A has been described to modulate gene expression, differentiation and function of diverse immune cells; however, the underlying mechanisms are not fully elucidated. This review aims to summarize the most updated advances on elucidating the vitamin A effects targeting intestinal immune and barrier functions, which may help in further understanding the burdens of malnutrition and enteric infections in children. Specifically, by covering both clinical and in vivo/in vitro data, we describe the effects of vitamin A related to gut immune tolerance/homeostasis, intestinal barrier integrity, and responses to enteropathogens in the context of the environmental enteric dysfunction. Some of the gaps in the literature that require further research are also highlighted.
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DOI：
10.4049/jimmunol.1402623
发表时间：
2015-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Guerra-Pérez N;Frank I;Veglia F;Aravantinou M;Goode D;Blanchard JL;Gettie A;Robbiani M;Martinelli E
通讯作者：
Martinelli E
影响因子：
3.7
作者：
Guerrant RL;Leite AM;Pinkerton R;Medeiros PH;Cavalcante PA;DeBoer M;Kosek M;Duggan C;Gewirtz A;Kagan JC;Gauthier AE;Swann J;Mayneris-Perxachs J;Bolick DT;Maier EA;Guedes MM;Moore SR;Petri WA;Havt A;Lima IF;Prata MM;Michaleckyj JC;Scharf RJ;Sturgeon C;Fasano A;Lima AA
通讯作者：
Lima AA
影响因子：
5.9
作者：
Borel P;Desmarchelier C
通讯作者：
Desmarchelier C
影响因子：
5.5
作者：
Arts, Rob J. W.;Blok, Bastiaan A.;Netea, Mihai G.
通讯作者：
Netea, Mihai G.
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo