Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil.
Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil.
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DOI：
10.1371/journal.pone.0158772
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Lima AA
中科院分区：
文献类型：
--
作者：
Guerrant RL;Leite AM;Pinkerton R;Medeiros PH;Cavalcante PA;DeBoer M;Kosek M;Duggan C;Gewirtz A;Kagan JC;Gauthier AE;Swann J;Mayneris-Perxachs J;Bolick DT;Maier EA;Guedes MM;Moore SR;Petri WA;Havt A;Lima IF;Prata MM;Michaleckyj JC;Scharf RJ;Sturgeon C;Fasano A;Lima AA
对于设计和评估肠道病干预措施及其对贫困儿童的发育后果至关重要的是，非侵入性生物标志物可以检测肠道损伤并预测其对生长和发育的影响。因此，我们评估了巴西东北部375名6-26个月不同程度营养不良（发育迟缓或萎缩）儿童的粪便、尿液和肠道病的全身生物标志物和生长预测因子。其中301名儿童在2-6米后返回进行了随访人体测量。与发育迟缓相关的生物标志物包括血浆IgA抗lps和抗flc， zonulin（如果bb0 - 12m）和肠道FABP （I-FABP，表明先前屏障破坏）；瓜氨酸、色氨酸和血清淀粉样蛋白A （SAA）降低（表明防御能力受损）。相比之下，粪便MPO或A1AT较高以及L/M、血浆LPS、I-FABP和SAA较高（显示肠屏障破坏和炎症）的患者可预测随后的生长。血浆瓜氨酸较高的女孩和血浆色氨酸较高的男孩生长较好。粪便中MPO和新蝶呤的相互作用也可以预测随后的生长损害。生物标志物聚集为1)功能性肠屏障破坏和易位标记，2)结构性肠屏障破坏和炎症标记，3)全身性炎症标记。主成分通路分析还表明，L/M与%L、I-FABP和MPO相关，与生长受损有关，同时（像MPO一样）与犬尿氨酸、LBP、sCD14、SAA和K/T的系统性炎症群相关。系统性证据表明，脂多糖易位与发育迟缓有关，而屏障破坏或修复的标志物（A1AT和Reg1与低带蛋白）与粪便MPO和neopterin有关。我们得出结论，肠屏障破坏、LPS易位以及肠道和全身性炎症的关键非侵入性生物标志物可以帮助阐明我们如何识别、理解和评估肠道病的有效干预措施及其在贫困环境下儿童的生长和发育后果。
Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth and development. We therefore assessed fecal, urinary and systemic biomarkers of enteropathy and growth predictors in 375 6–26 month-old children with varying degrees of malnutrition (stunting or wasting) in Northeast Brazil. 301 of these children returned for followup anthropometry after 2-6m. Biomarkers that correlated with stunting included plasma IgA anti-LPS and anti-FliC, zonulin (if >12m old), and intestinal FABP (I-FABP, suggesting prior barrier disruption); and with citrulline, tryptophan and with lower serum amyloid A (SAA) (suggesting impaired defenses). In contrast, subsequent growth was predicted in those with higher fecal MPO or A1AT and also by higher L/M, plasma LPS, I-FABP and SAA (showing intestinal barrier disruption and inflammation). Better growth was predicted in girls with higher plasma citrulline and in boys with higher plasma tryptophan. Interactions were also seen with fecal MPO and neopterin in predicting subsequent growth impairment. Biomarkers clustered into markers of 1) functional intestinal barrier disruption and translocation, 2) structural intestinal barrier disruption and inflammation and 3) systemic inflammation. Principle components pathway analyses also showed that L/M with %L, I-FABP and MPO associate with impaired growth, while also (like MPO) associating with a systemic inflammation cluster of kynurenine, LBP, sCD14, SAA and K/T. Systemic evidence of LPS translocation associated with stunting, while markers of barrier disruption or repair (A1AT and Reg1 with low zonulin) associated with fecal MPO and neopterin. We conclude that key noninvasive biomarkers of intestinal barrier disruption, LPS translocation and of intestinal and systemic inflammation can help elucidate how we recognize, understand, and assess effective interventions for enteropathy and its growth and developmental consequences in children in impoverished settings.
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影响因子：
6.7
作者：
Chevalier MF;Petitjean G;Dunyach-Rémy C;Didier C;Girard PM;Manea ME;Campa P;Meyer L;Rouzioux C;Lavigne JP;Barré-Sinoussi F;Scott-Algara D;Weiss L
通讯作者：
Weiss L
影响因子：
1.8
作者：
Benzoni N;Korpe P;Thakwalakwa C;Maleta K;Stephenson K;Manary M;Manary M
通讯作者：
Manary M
DOI：
10.1097/00005176-200408000-00005
发表时间：
2004-08-01
影响因子：
2.9
作者：
Campbell, DI;McPhail, G;Jeffries, DJ
通讯作者：
Jeffries, DJ
影响因子：
5.8
作者：
He, Q;Horlick, M;Gallagher, D
通讯作者：
Gallagher, D
影响因子：
6.4
作者：
Burgess SL;Buonomo E;Carey M;Cowardin C;Naylor C;Noor Z;Wills-Karp M;Petri WA Jr
通讯作者：
Petri WA Jr