Disentangling the effects of age and mild traumatic brain injury on brain network connectivity: A resting state fMRI study.
Disentangling the effects of age and mild traumatic brain injury on brain network connectivity: A resting state fMRI study.
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DOI：
10.1016/j.nicl.2020.102534
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
van der Naalt J
中科院分区：
文献类型：
--
作者：
Bittencourt-Villalpando M;van der Horn HJ;Maurits NM;van der Naalt J
衰老对大脑网络连通性的影响比轻度创伤性脑损伤（mTBI）更为强烈。
衰老的影响在默认模式和认知领域最为明显。
mTBI可能会改变小脑网络的频谱。
轻度创伤性脑损伤（mTBI）后不久，认知障碍较为常见，且可能持续数年。与年龄相关的认知衰退会使这些症状恶化。然而，年龄对mTBI后遗症的影响却鲜有研究。
对54名mTBI患者（中位年龄：35岁，范围19 - 64岁，67%为男性）和20名年龄及性别匹配的健康对照者在亚急性期进行了静息态功能磁共振成像研究。采用独立成分分析来识别内在连接网络（ICNs）。采用多变量方法从（静态）功能网络连接性（FNC）、空间图强度（SMs）和时间进程频谱功率（TC）方面评估年龄和组别对ICNs的影响。
我们观察到与年龄相关的显著变化：a）FNC：10对ICNs之间存在变化，主要涉及默认模式（DM）和/或认知控制（CC）领域；b）SMs：三个领域的集群强度降低，两个领域（包括CC但不包括DM）的集群强度增加；c）TC：位于额叶区域（包括前DM）的网络内，随着年龄增长，0 - 0.15Hz范围内频谱功率降低，0.20 - 0.25Hz范围内频谱功率增加。组别仅在小脑ICN的0.065 - 0.10Hz范围内的TC上存在差异，未发现年龄×组别交互作用。
我们发现年龄对与认知功能相关的ICNs之间及内部的连接性有显著影响。mTBI患者和对照组之间仅在小脑网络活动方面存在差异，而小脑网络越来越被认为参与认知。我们的研究结果表明，为了能够捕捉到与mTBI相关的真实影响及其对认知功能的影响，在mTBI研究中，除了进行年龄匹配分组外，还应将年龄作为协变量纳入研究。
Aging affects brain network connectivity more strongly than mTBI. Effects of aging are most evident in the default mode and cognitive domains. mTBI might alter the frequency spectrum of the cerebellar network. Cognitive complaints are common shortly after mild traumatic brain injury (mTBI) but may persist up to years. Age-related cognitive decline can worsen these symptoms. However, effects of age on mTBI sequelae have scarcely been investigated. Fifty-four mTBI patients (median age: 35 years, range 19–64 years, 67% male) and twenty age- and sex-matched healthy controls were studied using resting state functional magnetic resonance imaging in the sub-acute phase. Independent component analysis was used to identify intrinsic connectivity networks (ICNs). A multivariate approach was adopted to evaluate the effects of age and group on the ICNs in terms of (static) functional network connectivity (FNC), intensities of spatial maps (SMs) and time-course spectral power (TC). We observed significant age-related changes for a) FNC: changes between 10 pairs of ICNs, mostly involving the default mode (DM) and/or the cognitive-control (CC) domains; b) SMs: intensity decrease in clusters across three domains and intensity increase in clusters across two domains, including the CC but not the DM and c) TC: spectral power decrease within the 0–0.15 Hz range and increase within the 0.20–0.25 Hz range for increasing age within networks located in frontal areas, including the anterior DM. Groups only differed for TC within the 0.065–0.10 Hz range in the cerebellar ICN and no age × group interaction effect was found. We showed robust effects of age on connectivity between and within ICNs that are associated with cognitive functioning. Differences between mTBI patients and controls were only found for activity in the cerebellar network, increasingly recognized to participate in cognition. Our results suggest that to allow for capturing the true effects related to mTBI and its effects on cognitive functioning, age should be included as a covariate in mTBI studies, in addition to age-matching groups.
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影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
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DOI：
10.1016/j.nicl.2020.102375
发表时间：
2020
期刊：
NeuroImage. Clinical
影响因子：
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作者：
Du Y;Fu Z;Sui J;Gao S;Xing Y;Lin D;Salman M;Abrol A;Rahaman MA;Chen J;Hong LE;Kochunov P;Osuch EA;Calhoun VD;Alzheimer's Disease Neuroimaging Initiative
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Alzheimer's Disease Neuroimaging Initiative
DOI：
10.1073/pnas.1415122111
发表时间：
2014-11-18
影响因子：
11.1
作者：
Chan, Micaela Y.;Park, Denise C.;Wig, Gagan S.
通讯作者：
Wig, Gagan S.
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
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Lindenberger, U
DOI：
10.1016/j.cortex.2012.05.022
发表时间：
2013-05
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
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作者：
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通讯作者：
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