Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain.
Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain.
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DOI：
10.1007/s00429-018-1648-7
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发表时间：
2018-07
影响因子：
3.1
通讯作者：
Martina M
中科院分区：
文献类型：
--
作者：
Kelly CJ;Martina M
前额叶皮层（PFC）的功能失活是神经病理性疼痛表型的关键步骤。我们进行了光遗传学电路解剖研究腹侧海马（vHipp）和丘脑（MDTh）输入急性mPFC切片中的L5锥体细胞的特性，并测试这些输入的改变是否有助于mPFC失活神经性疼痛。我们发现：1-vHipp和MDTh输入都能引起单突触兴奋性和多突触抑制性电流。2-兴奋性MDTh输入的强度是均匀的，而vHipp输入沿背腹轴沿着逐渐变强。3-突触电流动力学表明，MDTh输入接触远端，而vHipp输入接触近端树突状部分。4-与MDTh输入相比，响应于vHipp的抑制电流的较长延迟表明它们分别由反馈和前馈电路激活。5-周围神经损伤（SNI）后一周，两个神经元的输入被修改：MDTh反应较小，没有突触前变化的证据，而在vHipp-mPFC突触释放的概率变低，电流幅度没有显着变化。因此，这两种输入的失调可能有助于神经性疼痛中的mPFC失活，并可能损害PFC依赖的认知任务。
Functional deactivation of the prefrontal cortex (PFC) is a critical step in the neuropathic pain phenotype. We performed optogenetic circuit dissection to study the properties of ventral hippocampal (vHipp) and thalamic (MDTh) inputs to L5 pyramidal cells in acute mPFC slices and to test whether alterations in these inputs contribute to mPFC deactivation in neuropathic pain. We found that: 1- Both the vHipp and MDTh inputs elicit monosynaptic excitatory and polysynaptic inhibitory currents. 2- The strength of the excitatory MDTh input is uniform, while the vHipp input becomes progressively stronger along the dorsal-ventral axis. 3- Synaptic current kinetics suggests that the MDTh inputs contact distal, while the vHipp inputs contact proximal dendritic sections. 4- The longer delay of inhibitory currents in response to vHipp compared to MDTh inputs suggests that they are activated by feedback and feedforward circuitries, respectively. 5- One week after a peripheral neuropathic injury (SNI), both glutamatergic inputs are modified: MDTh responses are smaller, without evidence of presynaptic changes, while the probability of release at vHipp-mPFC synapses becomes lower, without significant change in current amplitude. Thus, dysregulation of both these inputs likely contributes to the mPFC deactivation in neuropathic pain and may impair PFC-dependent cognitive tasks.
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影响因子：
3.4
作者：
Cheriyan J;Kaushik MK;Ferreira AN;Sheets PL
通讯作者：
Sheets PL
DOI：
10.1523/jneurosci.0587-12.2012
发表时间：
2012-04-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Mutso AA;Radzicki D;Baliki MN;Huang L;Banisadr G;Centeno MV;Radulovic J;Martina M;Miller RJ;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
2.5
作者：
Ji, Guangchen;Neugebauer, Volker
通讯作者：
Neugebauer, Volker
影响因子：
64.8
作者：
Petreanu, Leopoldo;Mao, Tianyi;Svoboda, Karel
通讯作者：
Svoboda, Karel
影响因子：
3.1
作者：
Karp, Jordan F.;Reynolds, Charles F., II;Weiner, Debra K.
通讯作者：
Weiner, Debra K.