Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.
Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.
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有关T调节细胞的最小信息：迈向可重复性和标准化的一步。
DOI：
10.3389/fimmu.2017.01844
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发表时间：
2017
影响因子：
7.3
通讯作者：
Trzonkowski P
中科院分区：
文献类型：
--
作者：
Fuchs A;Gliwiński M;Grageda N;Spiering R;Abbas AK;Appel S;Bacchetta R;Battaglia M;Berglund D;Blazar B;Bluestone JA;Bornhäuser M;Ten Brinke A;Brusko TM;Cools N;Cuturi MC;Geissler E;Giannoukakis N;Gołab K;Hafler DA;van Ham SM;Hester J;Hippen K;Di Ianni M;Ilic N;Isaacs J;Issa F;Iwaszkiewicz-Grześ D;Jaeckel E;Joosten I;Klatzmann D;Koenen H;van Kooten C;Korsgren O;Kretschmer K;Levings M;Marek-Trzonkowska NM;Martinez-Llordella M;Miljkovic D;Mills KHG;Miranda JP;Piccirillo CA;Putnam AL;Ritter T;Roncarolo MG;Sakaguchi S;Sánchez-Ramón S;Sawitzki B;Sofronic-Milosavljevic L;Sykes M;Tang Q;Vives-Pi M;Waldmann H;Witkowski P;Wood KJ;Gregori S;Hilkens CMU;Lombardi G;Lord P;Martinez-Caceres EM;Trzonkowski P
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications.
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影响因子：
3.3
作者：
Marek, Natalia;Bieniaszewska, Maria;Trzonkowski, Piotr
通讯作者：
Trzonkowski, Piotr
影响因子：
15.9
作者：
MacDonald, Katherine G.;Hoeppli, Romy E.;Levings, Megan K.
通讯作者：
Levings, Megan K.
影响因子：
4.6
作者：
Marek-Trzonkowska N;Piekarska K;Filipowicz N;Piotrowski A;Gucwa M;Vogt K;Sawitzki B;Siebert J;Trzonkowski P
通讯作者：
Trzonkowski P
DOI：
10.1111/ajt.12433
发表时间：
2013-11
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Putnam AL;Safinia N;Medvec A;Laszkowska M;Wray M;Mintz MA;Trotta E;Szot GL;Liu W;Lares A;Lee K;Laing A;Lechler RI;Riley JL;Bluestone JA;Lombardi G;Tang Q
通讯作者：
Tang Q
DOI：
10.1111/ajt.14415
发表时间：
2017-11
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Chandran S;Tang Q;Sarwal M;Laszik ZG;Putnam AL;Lee K;Leung J;Nguyen V;Sigdel T;Tavares EC;Yang JYC;Hellerstein M;Fitch M;Bluestone JA;Vincenti F
通讯作者：
Vincenti F