Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour
Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour
复制标题
黑质神经黑色素：结构、合成和分子行为
DOI：
10.1136/mp.54.6.414
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
D. Sulzer
中科院分区：
文献类型：
--
作者：
L. Zecca;D. Tampellini;M. Gerlach;P. Riederer;R. Fariello;D. Sulzer
黑质着色神经元在帕金森氏病中典型地消失；然而，神经元脆弱性与神经黑素的存在之间的可能关系尚未阐明。早期的组织学研究表明，在高等哺乳动物中，随着年龄的增长，黑质中神经黑色素的数量不断增加，神经黑素颗粒被一层膜包围，并比较评估了不同动物黑质的色素沉着。组织化学研究表明，神经黑色素与脂褐素有关。然而，对神经黑色素的结构、合成和分子相互作用的系统研究只是在过去的十年里才进行的。在这些后来的研究中，神经黑色素被鉴定为一种真正的黑色素，对铁具有很强的螯合能力，并对脂类、农药和MPP+等化合物具有亲和力。神经黑色素对各种无机和有机毒素的亲和力与对神经黑色素的保护功能是一致的。此外，老化过程中神经黑色素在神经元中的积累及其合成与胞浆中儿茶酚浓度较高之间的联系表明了一种保护作用。然而，在毒素超载的情况下，其假定的神经保护作用可能被猝灭。
The pigmented neurones of the substantia nigra are typically lost in Parkinson's disease; however, the possible relation between neuronal vulnerability and the presence of neuromelanin has not been elucidated. Early histological studies revealed the presence of increasing amounts of neuromelanin in the substantia nigra with aging in higher mammals, showed that the neuromelanin granules are surrounded by a membrane, and comparatively evaluated the pigmentation of the substantia nigra in different animal species. Histochemical studies showed the association of neuromelanin with lipofuscins. However, systematic investigations of the structure, synthesis, and molecular interactions of neuromelanin have been undertaken only during the past decade. In these later studies, neuromelanin was identified as a genuine melanin with a strong chelating ability for iron and an affinity for compounds such as lipids, pesticides, and MPP+. The affinity of neuromelanin for a variety of inorganic and organic toxins is consistent with a postulated protective function for neuromelanin. Moreover, the neuronal accumulation of neuromelanin during aging and the link between its synthesis and a high cytosolic concentration of catechols suggest a protective role. However, its putative neuroprotective effects could be quenched in conditions of toxin overload.
影响因子：
56.9
作者：
DAMATO, RJ;LIPMAN, ZP;SNYDER, SH
通讯作者：
SNYDER, SH
DOI：
10.1016/s0169-328x(96)00308-7
发表时间：
1997-04
期刊：
Brain research. Molecular brain research
影响因子：
--
作者：
Y. Xu;A. Stokes;W. Freeman;S. Kumer;B. Vogt;K. Vrana
通讯作者：
Y. Xu;A. Stokes;W. Freeman;S. Kumer;B. Vogt;K. Vrana