The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin.
The Ebola virus glycoprotein and HIV-1 Vpu employ different strategies to counteract the antiviral factor tetherin.
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埃博拉病毒糖蛋白和HIV-1 VPU采用不同的策略来抵消抗病毒因子Tetherin。
DOI：
10.1093/infdis/jir378
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Pöhlmann S
中科院分区：
文献类型：
--
作者：
Kühl A;Banning C;Marzi A;Votteler J;Steffen I;Bertram S;Glowacka I;Konrad A;Stürzl M;Guo JT;Schubert U;Feldmann H;Behrens G;Schindler M;Pöhlmann S
The antiviral protein tetherin/BST2/CD317/HM1.24 restricts cellular egress of human immunodeficiency virus (HIV) and of particles mimicking the Ebola virus (EBOV), a hemorrhagic fever virus. The HIV-1 viral protein U (Vpu) and the EBOV-glycoprotein (EBOV-GP) both inhibit tetherin. Here, we compared tetherin counteraction by EBOV-GP and Vpu. We found that EBOV-GP but not Vpu counteracted tetherin from different primate species, indicating that EBOV-GP and Vpu target tetherin differentially. Tetherin interacted with the GP2 subunit of EBOV-GP, which might encode the determinants for tetherin counteraction. Vpu reduced cell surface expression of tetherin while EBOV-GP did not, suggesting that both proteins employ different mechanisms to counteract tetherin. Finally, Marburg virus (MARV)–GP also inhibited tetherin and downregulated tetherin in a cell type–dependent fashion, indicating that tetherin antagonism depends on the cellular source of tetherin. Collectively, our results indicate that EBOV-GP counteracts tetherin by a novel mechanism and that tetherin inhibition is conserved between EBOV-GP and MARV-GP.
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影响因子：
3.7
作者：
Banning C;Votteler J;Hoffmann D;Koppensteiner H;Warmer M;Reimer R;Kirchhoff F;Schubert U;Hauber J;Schindler M
通讯作者：
Schindler M
影响因子：
30.3
作者：
Hinz A;Miguet N;Natrajan G;Usami Y;Yamanaka H;Renesto P;Hartlieb B;McCarthy AA;Simorre JP;Göttlinger H;Weissenhorn W
通讯作者：
Weissenhorn W
DOI：
10.1073/pnas.0907075106
发表时间：
2009-12-08
影响因子：
11.1
作者：
Gupta, Ravindra K.;Mlcochova, Petra;Towers, Greg J.
通讯作者：
Towers, Greg J.
影响因子：
5.4
作者：
Mansouri, Mandana;Viswanathan, Kasinath;Frueh, Klaus
通讯作者：
Frueh, Klaus
影响因子：
30.3
作者：
Goffinet, Christine;Allespach, Ina;Keppler, Oliver T.
通讯作者：
Keppler, Oliver T.