Global seroprevalence and sociodemographic characteristics of Borrelia burgdorferi sensu lato in human populations: a systematic review and meta-analysis.
Global seroprevalence and sociodemographic characteristics of Borrelia burgdorferi sensu lato in human populations: a systematic review and meta-analysis.
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DOI：
10.1136/bmjgh-2021-007744
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发表时间：
2022-06
影响因子：
8.1
通讯作者：
Bao F
中科院分区：
文献类型：
--
作者：
Dong Y;Zhou G;Cao W;Xu X;Zhang Y;Ji Z;Yang J;Chen J;Liu M;Fan Y;Kong J;Wen S;Li B;Yue P;Liu A;Bao F
伯氏疏螺旋体 (Bb) 感染是最常见的蜱传播疾病，分布于世界各地。本研究旨在描述 Bb 在人群中的全球血清流行率和社会人口学特征。我们使用以下关键词在 PubMed、Embase、Web of Science 和其他来源中搜索了截至 2021 年 12 月 30 日所有研究设计的相关研究：“伯氏疏螺旋体”和“感染率”；如果报告了人类 Bb 抗体血清阳性率调查的结果、报告了实验室血清学检测方法并在同行评审的期刊上发表，则纳入观察性研究。我们筛选了论文的标题/摘要和全文，并使用 Cochrane 协作组织认可的纽卡斯尔-渥太华质量评估量表评估了偏见风险。数据以叙述方式综合，并按不同类型的结果分层。我们还进行了随机效应荟萃分析，其中至少有两项研究报告了 95% CI。该研究方案已在 PROSPERO 注册（CRD42021261362）。在 4196 项研究中，137 项符合全文筛选条件，89 项（158 287 名个体）纳入荟萃分析。报告估计全球 Bb 血清流行率为 14.5%（95% CI 12.8% 至 16.3%），Bb 血清流行率排名前三位的地区是中欧（20.7%，95% CI 13.8% 至 28.6%）、东亚（15.9%，95% CI 6.6% 至 28.3%）和西欧（13.5%，95% CI 9.5% 至 18.0%）。 Meta回归分析显示，在消除混杂危险因素后，该方法缺乏蛋白质印迹（WB）确认，与使用WB确认的方法相比，增加了Bb抗体检测假阳性的风险（OR 1.9，95% CI 1.6至2.2）。与 Bb 血清阳性相关的其他因素包括年龄 ≥50 岁（12.6%，95% CI 8.0% 至 18.1%）、男性（7.8%，95% CI 4.6% 至 11.9%）、居住在农村地区（8.4%，95% CI 5.0% 至 12.6%）以及遭受蜱虫叮咬（18.8%，95% CI） 10.1% 至 29.4%）。报告估计全球Bb血清阳性率较高，排名前三的地区为中欧、西欧和东亚。使用WB来确认Bb血清学结果可以显着提高准确性。需要更多的研究来提高全球莱姆疏螺旋体病负担估计的准确性。 CRD42021261362。
Borrelia burgdorferi sensu lato (Bb) infection, the most frequent tick-transmitted disease, is distributed worldwide. This study aimed to describe the global seroprevalence and sociodemographic characteristics of Bb in human populations. We searched PubMed, Embase, Web of Science and other sources for relevant studies of all study designs through 30 December 2021 with the following keywords: ‘Borrelia burgdorferi sensu lato’ AND ‘infection rate’; and observational studies were included if the results of human Bb antibody seroprevalence surveys were reported, the laboratory serological detection method reported and be published in a peer-reviewed journal. We screened titles/abstracts and full texts of papers and appraised the risk of bias using the Cochrane Collaboration-endorsed Newcastle-Ottawa Quality Assessment Scale. Data were synthesised narratively, stratified by different types of outcomes. We also conducted random effects meta-analysis where we had a minimum of two studies with 95% CIs reported. The study protocol has been registered with PROSPERO (CRD42021261362). Of 4196 studies, 137 were eligible for full-text screening, and 89 (158 287 individuals) were included in meta-analyses. The reported estimated global Bb seroprevalence was 14.5% (95% CI 12.8% to 16.3%), and the top three regions of Bb seroprevalence were Central Europe (20.7%, 95% CI 13.8% to 28.6%), Eastern Asia (15.9%, 95% CI 6.6% to 28.3%) and Western Europe (13.5%, 95% CI 9.5% to 18.0%). Meta-regression analysis showed that after eliminating confounding risk factors, the methods lacked western blotting (WB) confirmation and increased the risk of false-positive Bb antibody detection compared with the methods using WB confirmation (OR 1.9, 95% CI 1.6 to 2.2). Other factors associated with Bb seropositivity include age ≥50 years (12.6%, 95% CI 8.0% to 18.1%), men (7.8%, 95% CI 4.6% to 11.9%), residence of rural area (8.4%, 95% CI 5.0% to 12.6%) and suffering tick bites (18.8%, 95% CI 10.1% to 29.4%). The reported estimated global Bb seropositivity is relatively high, with the top three regions as Central Europe, Western Europe and Eastern Asia. Using the WB to confirm Bb serological results could significantly improve the accuracy. More studies are needed to improve the accuracy of global Lyme borreliosis burden estimates. CRD42021261362.
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影响因子：
4.1
作者：
Bernard, Alexia;Kodjikian, Laurent;Seve, Pascal
通讯作者：
Seve, Pascal
影响因子：
3.2
作者：
Dersch, R.;Sarnes, A.;Rauer, S.
通讯作者：
Rauer, S.
影响因子：
1.2
作者：
Busova, Andrea;Dorko, Erik;Benhatchi, Karim
通讯作者：
Benhatchi, Karim
DOI：
10.1073/pnas.1718595115
发表时间：
2018-04-17
影响因子：
11.1
作者：
Bernard, Quentin;Smith, Alexis A.;Pal, Utpal
通讯作者：
Pal, Utpal
影响因子：
3.2
作者：
De Keukeleire, Mathilde;Robert, Annie;Vanwambeke, Sophie O.
通讯作者：
Vanwambeke, Sophie O.