Impact of aging on the immune response to traumatic brain injury (AIm:TBI) study protocol.
Impact of aging on the immune response to traumatic brain injury (AIm:TBI) study protocol.
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DOI：
10.1136/injuryprev-2019-043325
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Temkin N
中科院分区：
文献类型：
--
作者：
Thompson HJ;Rivara F;Becker KJ;Maier R;Temkin N
老年人的创伤性脑损伤（TBI）会导致相当大的发病率和死亡率。患有 TBI 的老年人的预后明显比年轻人差。对损伤的免疫反应的差异至少可以解释这种差异的部分原因。本研究的目的是了解衰老如何不同地影响 TBI 的免疫反应，以及老年和这些免疫变化如何影响 TBI 后恢复的自然史。前瞻性多队列设计正在用于评估衰老和创伤性脑损伤对免疫标志物的影响，并测试轻度创伤性脑损伤后老年人损伤和残疾的预测因素。患有轻度 TBI 的老年人（≥ 55 岁）分为三个对照组：患有轻度 TBI 的年轻人（21-54 岁）、未受伤的老年人（≥ 55 岁）和未受伤的年轻人（21-54 岁）。对于初步分析，我们将使用逻辑回归评估免疫标记物与 6 个月扩展格拉斯哥结果量表之间的关联。感兴趣的预测因子将是炎症生物标志物。多元线性回归将用于评估 3 个月和 6 个月时生物标志物与其他结果（症状、功能和生活质量）之间的关联。探索性分析将调查生物标志物使用 ROC 曲线预测结果的效用。更好地了解老年人 TBI 后不同结果的恢复轨迹和生物学原理，可以帮助制定旨在减少或消除症状的具体干预措施。此类干预措施可以减少损伤和医疗费用。
Traumatic brain injury (TBI) in older adults leads to considerable morbidity and mortality. Outcomes among older adults with TBI are disparately worse than in younger adults. Differences in immunologic response to injury may account for at least some of this disparity. Understanding how aging differentially affects the immune response to TBI and how older age and these immunologic changes affect the natural history of recovery following TBI are the goals of this study. A prospective multiple cohort design is being used to assess the effects of aging and TBI on immune makers and to test predictors of impairment and disability in older adults following mild TBI. Older adults (≥ 55 years) with mild TBI are enrolled with three comparison groups: younger adults (21–54 years) with mild TBI, non-injured older adults (≥ 55 years) and non-injured young adults (21–54 years). For the primary analysis, we will assess the association between immune markers and Glasgow Outcome Scale-Extended at 6 months, using logistic regression. Predictors of interest will be inflammatory biomarkers. Multivariate linear regression will be used to evaluate associations between biomarkers and other outcomes (symptoms, function and quality of life) at 3 and 6 months. Exploratory analyses will investigate the utility of biomarkers to predict outcome using ROC curves. A better understanding of the recovery trajectory and biological rationale for disparate outcomes following TBI in older adults could allow for development of specific interventions aimed at reducing or eliminating symptoms. Such interventions could reduce impairment and health care costs.
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DOI：
10.1097/01.bcr.0000150214.72984.44
发表时间：
2005-01-01
期刊：
JOURNAL OF BURN CARE & REHABILITATION
影响因子：
--
作者：
Gosain, A;Gamelli, RL
通讯作者：
Gamelli, RL
DOI：
10.1007/bf01997792
发表时间：
1996-08-01
期刊：
ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES
影响因子：
--
作者：
Giovagnoli, AR;DelPesce, M;Capitani, E
通讯作者：
Capitani, E
影响因子：
6.3
作者：
Bermpohl, Daniela;You, Zerong;Whalen, Michael J.
通讯作者：
Whalen, Michael J.
DOI：
10.1097/00005373-197611000-00006
发表时间：
1976-01-01
影响因子：
--
作者：
BAKER, SP;ONEILL, B
通讯作者：
ONEILL, B
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y