Blood Pressure Modulation With Low-Intensity Focused Ultrasound Stimulation to the Vagus Nerve: A Pilot Animal Study.
Blood Pressure Modulation With Low-Intensity Focused Ultrasound Stimulation to the Vagus Nerve: A Pilot Animal Study.
复制标题
通过低强度聚焦超声刺激迷走神经来调节血压：一项试点动物研究
DOI：
10.3389/fnins.2020.586424
复制
发表时间：
2020
影响因子：
4.3
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Ji N;Lin WH;Chen F;Xu L;Huang J;Li G
对于高血压患者，他们的血压（BP）通常通过服药来控制。然而，降压药可能会引起诸如充血性心力衰竭等不良反应，并且对大量高血压人群无效。作为一种高血压管理的替代方法，基于非药物装置的神经调节方法，如功能性电刺激（FES）已经被提出。FES方法需要将刺激器植入体内。一种最近新兴的技术，称为低强度聚焦超声刺激（FUS），已被提出用于无创地调节神经活动。在这项初步研究中，利用动物模型研究了采用低强度FUS神经调节来调节血压的可行性。
开发了一种用于调节兔子血压的FUS系统。对于每只兔子，使用不同声强的低强度FUS刺激其暴露的左侧迷走神经，并在其右侧颈总动脉同步记录血压波形。从血压记录中广泛研究了不同FUS强度对收缩压（SBP）、舒张压（DBP）、平均血压（MAP）和心率（HR）的影响。
结果表明，所提出的FUS方法能够成功地引起SBP、DBP、MAP和HR值的变化。当增加声强时，SBP、DBP和MAP的值往往会更显著地降低。
这项研究的结果表明，血压可以通过FUS进行调节，这可能为高血压的无创和非药物管理提供一种新的途径。
ObjectiveFor hypertensive individuals, their blood pressure (BP) is often managed by taking medications. However, antihypertensive drugs might cause adverse effects such as congestive heart failure and are ineffective in significant numbers of the hypertensive population. As an alternative method for hypertension management, non-drug devices-based neuromodulation approaches such as functional electrical stimulation (FES) have been proposed. The FES approach requires the implantation of a stimulator into the body. One recently emerging technique, called low-intensity focused ultrasound stimulation (FUS), has been proposed to non-invasively modulate neural activities. In this pilot study, the feasibility of adopting low-intensity FUS neuromodulation for BP regulation was investigated using animal models.MethodsA FUS system was developed for BP modulation in rabbits. For each rabbit, the low-intensity FUS with different acoustic intensities was used to stimulate its exposed left vagus nerve, and the BP waveform was synchronously recorded in its right common carotid artery. The effects of the different FUS intensities on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MAP), and heart rate (HR) were extensively examined from the BP recordings.ResultsThe results demonstrated that the proposed FUS method could successfully induce changes in SBP, DBP, MAP, and HR values. When increasing acoustic intensities, the values of SBP, DBP, and MAP would tend to decrease more substantially.ConclusionThe findings of this study suggested that BP could be modulated through the FUS, which might provide a new way for non-invasive and non-drug management of hypertension.
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DOI：
10.1161/hypertensionaha.108.119859
发表时间：
2011-05
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Lohmeier TE;Iliescu R
通讯作者：
Iliescu R
影响因子：
24
作者：
Cai, Xingxing;Yang, Yuli;Li, Yi-Gang
通讯作者：
Li, Yi-Gang
影响因子：
3.3
作者：
Juan, Eduardo J.;Gonzalez, Rafael;Albors, Gabriel;Ward, Matthew P.;Irazoqui, Pedro
通讯作者：
Irazoqui, Pedro
影响因子：
24
作者：
Scheffers, Ingrid J. M.;Kroon, Abraham A.;de Leeuw, Peter W.
通讯作者：
de Leeuw, Peter W.
影响因子：
5.9
作者：
SMITHWICK, RH
通讯作者：
SMITHWICK, RH